1-<5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-3-C-(difluoromethyl)-2-fluoro-β-D-ribo-pentofuranosyl>uracil

Base Information

Chemical Name:1-<5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-3-C-(difluoromethyl)-2-fluoro-β-D-ribo-pentofuranosyl>uracil
CAS No.:129678-76-8
Molecular Formula:C₂₆H₂₉F₃N₂O₄Si
Molecular Weight:518.608
Hs Code.:

Synonyms:1-<5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-3-C-(difluoromethyl)-2-fluoro-β-D-ribo-pentofuranosyl>uracil

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-<5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-3-C-(difluoromethyl)-2-fluoro-β-D-ribo-pentofuranosyl>uracil

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Technology Process of 1-<5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-3-C-(difluoromethyl)-2-fluoro-β-D-ribo-pentofuranosyl>uracil

There total 5 articles about 1-<5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-3-C-(difluoromethyl)-2-fluoro-β-D-ribo-pentofuranosyl>uracil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 129678-73-5
1-<5-O-(tert-butyldiphenylsilyl)-3-deoxy-3-C-(difluoromethyl)-β-D-arabino-pentofuranosyl>uracil

: 129678-76-8
1-<5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-3-C-(difluoromethyl)-2-fluoro-β-D-ribo-pentofuranosyl>uracil

Guidance literature:: With diethylamino-sulfur trifluoride; In dichloromethane; for 1h; Ambient temperature;
DOI:10.1021/jm00171a024

Reference yield:

: 129678-63-3
1-<5-O-(tert-butyldiphenylsilyl)-3-deoxy-3-C-(4,5-dihydro-5-methyl-1,3,5-dithiazin-2-yl)-β-D-arabino-pentofuranosyl>uracil

: 129678-76-8
1-<5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-3-C-(difluoromethyl)-2-fluoro-β-D-ribo-pentofuranosyl>uracil

Guidance literature:: Multi-step reaction with 5 steps

1: 87 percent / p-toluenesulfonic acid monohydrate / dioxane / Ambient temperature

2: 72 percent / mercuric salts / 0.08 h / 0 °C

3: 88 percent / (diethylamino)sulfur trifluoride (DAST) / CH₂Cl₂ / 1.5 h / Ambient temperature

4: 50 percent / trifluoroacetic acid / butan-1-ol / 0.17 h / Ambient temperature

5: 72 percent / (diethylamino)sulfur trifluoride (DAST) / CH₂Cl₂ / 1 h / Ambient temperature

With diethylamino-sulfur trifluoride; mercuric salts; toluene-4-sulfonic acid; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; butan-1-ol;
DOI:10.1021/jm00171a024

Reference yield:

: 129678-71-3
1-<5-O-(tert-butyldiphenylsilyl)-3-deoxy-3-C-(difluoromethyl)-2-O-(4-methoxytetrahydropyran-4-yl)-β-D-arabino-pentofuranosyl>uracil

: 129678-76-8
1-<5-O-(tert-butyldiphenylsilyl)-2,3-dideoxy-3-C-(difluoromethyl)-2-fluoro-β-D-ribo-pentofuranosyl>uracil

Guidance literature:: Multi-step reaction with 2 steps

1: 50 percent / trifluoroacetic acid / butan-1-ol / 0.17 h / Ambient temperature

2: 72 percent / (diethylamino)sulfur trifluoride (DAST) / CH₂Cl₂ / 1 h / Ambient temperature

With diethylamino-sulfur trifluoride; trifluoroacetic acid; In dichloromethane; butan-1-ol;
DOI:10.1021/jm00171a024