rel-(4S,10S)-4-(6-bromo-3,4-dimethoxyphenyl)octahydro-4H-quinolizin-6-one

Base Information

Chemical Name:rel-(4S,10S)-4-(6-bromo-3,4-dimethoxyphenyl)octahydro-4H-quinolizin-6-one
CAS No.:80696-98-6
Molecular Formula:C₁₇H₂₂BrNO₃
Molecular Weight:368.271
Hs Code.:

Synonyms:rel-(4S,10S)-4-(6-bromo-3,4-dimethoxyphenyl)octahydro-4H-quinolizin-6-one

Suppliers and Price of rel-(4S,10S)-4-(6-bromo-3,4-dimethoxyphenyl)octahydro-4H-quinolizin-6-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of rel-(4S,10S)-4-(6-bromo-3,4-dimethoxyphenyl)octahydro-4H-quinolizin-6-one

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of rel-(4S,10S)-4-(6-bromo-3,4-dimethoxyphenyl)octahydro-4H-quinolizin-6-one

There total 11 articles about rel-(4S,10S)-4-(6-bromo-3,4-dimethoxyphenyl)octahydro-4H-quinolizin-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

: 688-73-3
tri-n-butyl-tin hydride

: 80696-97-5
rel-(2R,4S,10R)-4-(6-bromo-3,4-dimethoxyphenyl)-6-oxooctahydro-4H-quinolizin-2-yl S-methyl dithiocarbonate

: 80696-98-6
rel-(4S,10S)-4-(6-bromo-3,4-dimethoxyphenyl)octahydro-4H-quinolizin-6-one

Guidance literature:: With 2,2'-azobis(isobutyronitrile); In toluene; at 80 ℃; for 2h;
DOI:10.1021/jo00347a036

Reference yield:

: 80718-98-5
N-<1-(6-bromo-3,4-dimethoxyphenyl)but-3-en-1-yl>-5,5-dimethoxypentanamide

: 80696-98-6
rel-(4S,10S)-4-(6-bromo-3,4-dimethoxyphenyl)octahydro-4H-quinolizin-6-one

Guidance literature:: With formic acid; sodium acetate; toluene-4-sulfonic acid hydrazide; Yield given. Multistep reaction; 1.) CH₂Cl₂, RT, 4 h, 2.) ethanol, water, reflux, 5 h;
DOI:10.1021/jo00347a036

Reference yield:

: 23068-91-9
methyl 5,5-dimethoxyvalerate

: 80696-98-6
rel-(4S,10S)-4-(6-bromo-3,4-dimethoxyphenyl)octahydro-4H-quinolizin-6-one

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) trimethylaluminum / 1.) dichloromethane + heptane, RT, 30 min, 2.) reflux, 20 h

2: formic acid / CH₂Cl₂ / 4 h / Ambient temperature

3: 98 percent / 3N aq. sodium hydroxide / methanol / 1.25 h / Ambient temperature

4: 1.) sodium hydride, imidazole / 1.) THF, 60 deg C, 30 min, 2.) 60 deg C, 30 min

5: tetrahydrofuran / 0.5 h / 60 °C

6: 47 percent / 2,2'-azobis(2-methylpropionitrile) / toluene / 2 h / 80 °C

With 1H-imidazole; sodium hydroxide; formic acid; 2,2'-azobis(isobutyronitrile); trimethylaluminum; sodium hydride; In tetrahydrofuran; methanol; dichloromethane; toluene;
DOI:10.1021/jo00347a036