N-(1-(4-cyanophenyl)-3-methyl-1-oxobutan-2-yl)-1-methyl-1H-indole-2-carboxamide

Base Information

• Chemical Name: N-(1-(4-cyanophenyl)-3-methyl-1-oxobutan-2-yl)-1-methyl-1H-indole-2-carboxamide
• CAS No.: 1394017-43-6
• Molecular Formula: C₂₂H₂₁N₃O₂
• Molecular Weight: 359.428

Synonyms:N-(1-(4-cyanophenyl)-3-methyl-1-oxobutan-2-yl)-1-methyl-1H-indole-2-carboxamide

Chemical Property of N-(1-(4-cyanophenyl)-3-methyl-1-oxobutan-2-yl)-1-methyl-1H-indole-2-carboxamide

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Technology Process of N-(1-(4-cyanophenyl)-3-methyl-1-oxobutan-2-yl)-1-methyl-1H-indole-2-carboxamide

There total 2 articles about N-(1-(4-cyanophenyl)-3-methyl-1-oxobutan-2-yl)-1-methyl-1H-indole-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

4-(2-amino-3-methylbutanoyl)benzonitrile hydrochloride (1394017-92-5) + N-methyl-1H-indole-2-carboxylic acid (16136-58-6) → N-(1-(4-cyanophenyl)-3-methyl-1-oxobutan-2-yl)-1-methyl-1H-indole-2-carboxamide (1394017-43-6)

Guidance literature:

N-methyl-1H-indole-2-carboxylic acid; With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; for 0.0833333h;

4-(2-amino-3-methylbutanoyl)benzonitrile hydrochloride; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;

DOI:10.1016/j.bmcl.2012.07.032

Reference yield: 70.0%

4-(2-amino-3-methylbutanoyl)benzonitrile hydrochloride + N-methyl-1H-indole-2-carboxylic acid (16136-58-6) → N-(1-(4-cyanophenyl)-3-methyl-1-oxobutan-2-yl)-1-methyl-1H-indole-2-carboxamide (1394017-43-6)

Guidance literature:

N-methyl-1H-indole-2-carboxylic acid; With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.1h;

4-(2-amino-3-methylbutanoyl)benzonitrile hydrochloride; In N,N-dimethyl-formamide; for 3h;

Reference yield:

N-(1-(4-cyanophenyl)-3-methyl-1-oxobutan-2-yl)-1-methyl-1H-indole-2-carboxamide (1394017-43-6) → N-(1-(4-cyanophenyl)-3-methyl-1-oxobutan-2-yl)-1-methyl-1H-indole-2-carboxamide + N-(1-(4-cyanophenyl)-3-methyl-1-oxobutan-2-yl)-1-methyl-1H-indole-2-carboxamide

Guidance literature:

With Chiralpak AD-H; In methanol; carbon dioxide; Resolution of racemate; Supercritical conditions; liquid CO₂;

upstream raw materials:

4-(2-amino-3-methylbutanoyl)benzonitrile hydrochloride

N-methyl-1H-indole-2-carboxylic acid

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