(-)-(2E)-3-(4-chlorophenyl)-1-[(3aS,6R,7aR)tetrahydro-8,8-dimethyl-2,2-dioxido-3H-3a,6-methano-2,1-benzisothiazol-1(4H)-yl]prop-2-en-1-one

Base Information

Chemical Name:(-)-(2E)-3-(4-chlorophenyl)-1-[(3aS,6R,7aR)tetrahydro-8,8-dimethyl-2,2-dioxido-3H-3a,6-methano-2,1-benzisothiazol-1(4H)-yl]prop-2-en-1-one
CAS No.:153141-26-5
Molecular Formula:C₁₉H₂₂ClNO₃S
Molecular Weight:379.908
Hs Code.:

Synonyms:(-)-(2E)-3-(4-chlorophenyl)-1-[(3aS,6R,7aR)tetrahydro-8,8-dimethyl-2,2-dioxido-3H-3a,6-methano-2,1-benzisothiazol-1(4H)-yl]prop-2-en-1-one

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Chemical Property of (-)-(2E)-3-(4-chlorophenyl)-1-[(3aS,6R,7aR)tetrahydro-8,8-dimethyl-2,2-dioxido-3H-3a,6-methano-2,1-benzisothiazol-1(4H)-yl]prop-2-en-1-one

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Technology Process of (-)-(2E)-3-(4-chlorophenyl)-1-[(3aS,6R,7aR)tetrahydro-8,8-dimethyl-2,2-dioxido-3H-3a,6-methano-2,1-benzisothiazol-1(4H)-yl]prop-2-en-1-one

There total 9 articles about (-)-(2E)-3-(4-chlorophenyl)-1-[(3aS,6R,7aR)tetrahydro-8,8-dimethyl-2,2-dioxido-3H-3a,6-methano-2,1-benzisothiazol-1(4H)-yl]prop-2-en-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 35086-79-4,95602-71-4
cinnamoyl chloride

: 94594-90-8,124224-04-0
(2R)-bornane-10,2-sultam

: 153141-26-5
(-)-(2E)-3-(4-chlorophenyl)-1-[(3aS,6R,7aR)tetrahydro-8,8-dimethyl-2,2-dioxido-3H-3a,6-methano-2,1-benzisothiazol-1(4H)-yl]prop-2-en-1-one

Guidance literature:: (2R)-bornane-10,2-sultam; With sodium hydride; In toluene; mineral oil; at 0 - 20 ℃; for 0.5h; Inert atmosphere;

cinnamoyl chloride; In toluene; mineral oil; at 0 - 20 ℃; for 18h;
DOI:10.1002/hlca.201100197

Reference yield: 64.0%

: 1867-38-5
4-chlorobenzylidenemalonodinitrile

: 153897-27-9
4-[(6R,7aR)-8,8-dimethyl-2,2-dioxidotetrahydro-3a,6-methano-2,1-benzisothiazol-1(4H)-yl]-4-oxobutan-2-one

: 153141-26-5
(-)-(2E)-3-(4-chlorophenyl)-1-[(3aS,6R,7aR)tetrahydro-8,8-dimethyl-2,2-dioxido-3H-3a,6-methano-2,1-benzisothiazol-1(4H)-yl]prop-2-en-1-one

: 153897-33-7
(R)-2-amino-4-(p-chlorophenyl)-3-cyano-6-methyl-5-(N-oxobornane-10,2-sultam)-4H-pyran

Guidance literature:: piperidine; In toluene; Ambient temperature;
DOI:10.1016/S0040-4039(00)73900-1

Reference yield:

: 153897-28-0
(R)-2-amino-3-cyano-6-methyl-5-(N-oxobornane-10,2-sultam)-4-phenyl-4H-pyran

: 153141-26-5
(-)-(2E)-3-(4-chlorophenyl)-1-[(3aS,6R,7aR)tetrahydro-8,8-dimethyl-2,2-dioxido-3H-3a,6-methano-2,1-benzisothiazol-1(4H)-yl]prop-2-en-1-one

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / LiAlH₄ / diethyl ether; tetrahydrofuran / 3 h / 0 °C

2: 82 percent / toluene / 1 h / 130 °C

3: piperidine / toluene / Ambient temperature

With piperidine; lithium aluminium tetrahydride; In tetrahydrofuran; diethyl ether; toluene;
DOI:10.1016/S0040-4020(01)87029-0