(1R,2R)-2-[(R)-1-(4-Methoxy-benzyl)-2,5-dioxo-4-(2-m-tolyl-ethyl)-imidazolidin-4-yl]-cyclopropanecarboxylic acid 4-methoxy-benzyl ester

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Chemical Name:(1R,2R)-2-[(R)-1-(4-Methoxy-benzyl)-2,5-dioxo-4-(2-m-tolyl-ethyl)-imidazolidin-4-yl]-cyclopropanecarboxylic acid 4-methoxy-benzyl ester
CAS No.:178898-50-5
Molecular Formula:C₃₂H₃₄N₂O₆
Molecular Weight:542.632
Hs Code.:

Synonyms:(1R,2R)-2-[(R)-1-(4-Methoxy-benzyl)-2,5-dioxo-4-(2-m-tolyl-ethyl)-imidazolidin-4-yl]-cyclopropanecarboxylic acid 4-methoxy-benzyl ester

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Chemical Property of (1R,2R)-2-[(R)-1-(4-Methoxy-benzyl)-2,5-dioxo-4-(2-m-tolyl-ethyl)-imidazolidin-4-yl]-cyclopropanecarboxylic acid 4-methoxy-benzyl ester

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Technology Process of (1R,2R)-2-[(R)-1-(4-Methoxy-benzyl)-2,5-dioxo-4-(2-m-tolyl-ethyl)-imidazolidin-4-yl]-cyclopropanecarboxylic acid 4-methoxy-benzyl ester

There total 1 articles about (1R,2R)-2-[(R)-1-(4-Methoxy-benzyl)-2,5-dioxo-4-(2-m-tolyl-ethyl)-imidazolidin-4-yl]-cyclopropanecarboxylic acid 4-methoxy-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 824-94-2
p-methoxybenzyl chloride

: 201851-25-4
(5SR)-5-((1R,2R)-2-carboxycycloprop-1-yl)-5-[2-(3-methylphenyl)ethyl]imidazolidine-2,4-dione

: 178898-49-2
(1R,2R)-2-[(S)-1-(4-Methoxy-benzyl)-2,5-dioxo-4-(2-m-tolyl-ethyl)-imidazolidin-4-yl]-cyclopropanecarboxylic acid 4-methoxy-benzyl ester

: 178898-50-5
(1R,2R)-2-[(R)-1-(4-Methoxy-benzyl)-2,5-dioxo-4-(2-m-tolyl-ethyl)-imidazolidin-4-yl]-cyclopropanecarboxylic acid 4-methoxy-benzyl ester

Guidance literature:: With potassium hydrogencarbonate; In N,N-dimethyl-formamide; at 125 ℃;
DOI:10.1021/jm970498o

Reference yield: 42.0%

: 178898-50-5
(1R,2R)-2-[(R)-1-(4-Methoxy-benzyl)-2,5-dioxo-4-(2-m-tolyl-ethyl)-imidazolidin-4-yl]-cyclopropanecarboxylic acid 4-methoxy-benzyl ester

: 5R-5-(1R,2R-2-carboxycyclopropan-1-yl)-5-(2-(3-methylphenyl)ethyl)imidazolidine-2,4-dione

Guidance literature:: With ammonium cerium(IV) nitrate; In water; acetonitrile; for 2.5h; Ambient temperature;
DOI:10.1021/jm970498o

Reference yield:

: 178898-50-5
(1R,2R)-2-[(R)-1-(4-Methoxy-benzyl)-2,5-dioxo-4-(2-m-tolyl-ethyl)-imidazolidin-4-yl]-cyclopropanecarboxylic acid 4-methoxy-benzyl ester

: 2R-2-amino-2-(1R,2R-2-carboxycyclopropan-1-yl)-4-(3-methylphenyl)butanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 42 percent / ceric ammonium nitrate / acetonitrile; H₂O / 2.5 h / Ambient temperature

2: 19 percent / aq. Ba(OH)2 / 16 h / 250 °C

With barium dihydroxide; ammonium cerium(IV) nitrate; In water; acetonitrile;
DOI:10.1021/jm970498o