(4R)-4-(4-chloro-2-methylphenyl)-1-methyl-3-(2-pyridyl)-4,6,7,8-tetrahydropyrazolo[3,4-e][1,4]thiazepine

Base Information

Chemical Name:(4R)-4-(4-chloro-2-methylphenyl)-1-methyl-3-(2-pyridyl)-4,6,7,8-tetrahydropyrazolo[3,4-e][1,4]thiazepine
CAS No.:1616363-64-4
Molecular Formula:C₁₉H₁₉ClN₄S
Molecular Weight:370.906
Hs Code.:

Synonyms:(4R)-4-(4-chloro-2-methylphenyl)-1-methyl-3-(2-pyridyl)-4,6,7,8-tetrahydropyrazolo[3,4-e][1,4]thiazepine

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Chemical Property of (4R)-4-(4-chloro-2-methylphenyl)-1-methyl-3-(2-pyridyl)-4,6,7,8-tetrahydropyrazolo[3,4-e][1,4]thiazepine

Chemical Property:

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Technology Process of (4R)-4-(4-chloro-2-methylphenyl)-1-methyl-3-(2-pyridyl)-4,6,7,8-tetrahydropyrazolo[3,4-e][1,4]thiazepine

There total 5 articles about (4R)-4-(4-chloro-2-methylphenyl)-1-methyl-3-(2-pyridyl)-4,6,7,8-tetrahydropyrazolo[3,4-e][1,4]thiazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1616360-36-1
4-(4-chloro-2-methylphenyl)-1-methyl-3-(2-pyridyl)-4,8-dihydropyrazolo[3,4-e][1,4]thiazepin-7-one

: 1616363-64-4
(4R)-4-(4-chloro-2-methylphenyl)-1-methyl-3-(2-pyridyl)-4,6,7,8-tetrahydropyrazolo[3,4-e][1,4]thiazepine

: 1616363-65-5
(4S)-4-(4-chloro-2-methylphenyl)-1-methyl-3-(2-pyridyl)-4,6,7,8-tetrahydropyrazolo[3,4-e][1,4]thiazepine

Guidance literature:: With diethylamine; In n-heptane; isopropyl alcohol;

Reference yield:

: 2524-52-9,1228273-66-2
ethyl-2-picolinate

: 1616363-64-4
(4R)-4-(4-chloro-2-methylphenyl)-1-methyl-3-(2-pyridyl)-4,6,7,8-tetrahydropyrazolo[3,4-e][1,4]thiazepine

: 1616363-65-5
(4S)-4-(4-chloro-2-methylphenyl)-1-methyl-3-(2-pyridyl)-4,6,7,8-tetrahydropyrazolo[3,4-e][1,4]thiazepine

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydride / tetrahydrofuran; mineral oil / 5 h / 65 °C

2: ethanol / 18.5 h / 20 - 75 °C

3: acetonitrile / 0.33 h / 150 °C / Sealed tube; Microwave irradiation

4: diethylamine / n-heptane; isopropyl alcohol

With sodium hydride; diethylamine; In tetrahydrofuran; ethanol; n-heptane; isopropyl alcohol; acetonitrile; mineral oil;

Reference yield:

: 40137-29-9
2-methyl-4-chlorobenzaldehyde

: 1616363-64-4
(4R)-4-(4-chloro-2-methylphenyl)-1-methyl-3-(2-pyridyl)-4,6,7,8-tetrahydropyrazolo[3,4-e][1,4]thiazepine

: 1616363-65-5
(4S)-4-(4-chloro-2-methylphenyl)-1-methyl-3-(2-pyridyl)-4,6,7,8-tetrahydropyrazolo[3,4-e][1,4]thiazepine

Guidance literature:: Multi-step reaction with 2 steps

1: acetonitrile / 0.33 h / 150 °C / Sealed tube; Microwave irradiation

2: diethylamine / n-heptane; isopropyl alcohol

With diethylamine; In n-heptane; isopropyl alcohol; acetonitrile;