2-(5-(2,7-diazaspiro[3.5]nonan-2-yl)-1,3,4-thiadiazol-2-yl)-3-fluoro-5-(1H-pyrazol-4-yl)phenol

Base Information

Chemical Name:2-(5-(2,7-diazaspiro[3.5]nonan-2-yl)-1,3,4-thiadiazol-2-yl)-3-fluoro-5-(1H-pyrazol-4-yl)phenol
CAS No.:1620515-65-2
Molecular Formula:C₁₈H₁₉FN₆OS
Molecular Weight:386.453
Hs Code.:

Synonyms:2-(5-(2,7-diazaspiro[3.5]nonan-2-yl)-1,3,4-thiadiazol-2-yl)-3-fluoro-5-(1H-pyrazol-4-yl)phenol

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Chemical Property of 2-(5-(2,7-diazaspiro[3.5]nonan-2-yl)-1,3,4-thiadiazol-2-yl)-3-fluoro-5-(1H-pyrazol-4-yl)phenol

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Technology Process of 2-(5-(2,7-diazaspiro[3.5]nonan-2-yl)-1,3,4-thiadiazol-2-yl)-3-fluoro-5-(1H-pyrazol-4-yl)phenol

There total 6 articles about 2-(5-(2,7-diazaspiro[3.5]nonan-2-yl)-1,3,4-thiadiazol-2-yl)-3-fluoro-5-(1H-pyrazol-4-yl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1620516-12-2
tert-butyl 2-(5-(2,3-difluoro-4-(1H-pyrazol-4-yl)phenyl)-1,3,4-thiadiazol-2-yl)-2,7-diazaspiro[3.5]nonane-7-carboxylate

: 1620515-65-2
2-(5-(2,7-diazaspiro[3.5]nonan-2-yl)-1,3,4-thiadiazol-2-yl)-3-fluoro-5-(1H-pyrazol-4-yl)phenol

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; methanol; dimethyl sulfoxide; at 20 ℃; for 2h;

Reference yield:

: 896464-16-7
2,7-diaza-spiro[3.5]nonane-7-carboxylic acid tert-butyl ester

: 1620515-65-2
2-(5-(2,7-diazaspiro[3.5]nonan-2-yl)-1,3,4-thiadiazol-2-yl)-3-fluoro-5-(1H-pyrazol-4-yl)phenol

Guidance literature:: Multi-step reaction with 6 steps

1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 1 h / 120 °C

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; 1,4-dioxane / 1 h / 100 °C / Inert atmosphere; Sealed tube; Microwave irradiation

3: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 216 h / 2585.81 Torr / Inert atmosphere

4: triethylamine / dichloromethane / 21 h / 20 °C / Inert atmosphere; Cooling with ice

5: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; 1,4-dioxane / 1 h / 120 °C / Sealed tube; Microwave irradiation

6: hydrogenchloride / 1,4-dioxane; methanol; dimethyl sulfoxide / 2 h / 20 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; sodium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; methanol; dichloromethane; water; dimethyl sulfoxide; ethyl acetate;

Reference yield:

: 1620516-09-7
tert-butyl 2-(5-(4-(benzyloxy)-2,3-difluorophenyl)-1,3,4-thiadiazol-2-yl)-2,7-diazaspiro[3.5]nonane-7-carboxylate

: 1620515-65-2
2-(5-(2,7-diazaspiro[3.5]nonan-2-yl)-1,3,4-thiadiazol-2-yl)-3-fluoro-5-(1H-pyrazol-4-yl)phenol

Guidance literature:: Multi-step reaction with 4 steps

1: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 216 h / 2585.81 Torr / Inert atmosphere

2: triethylamine / dichloromethane / 21 h / 20 °C / Inert atmosphere; Cooling with ice

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; 1,4-dioxane / 1 h / 120 °C / Sealed tube; Microwave irradiation

4: hydrogenchloride / 1,4-dioxane; methanol; dimethyl sulfoxide / 2 h / 20 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; hydrogen; sodium carbonate; triethylamine; In 1,4-dioxane; methanol; dichloromethane; water; dimethyl sulfoxide; ethyl acetate;