(S)-2-(tert-Butyldiphenylsilyloxy)-3-<<2-(1H-indol-3-yl)ethyl>aminooxy>methylthiol-propanal diethyl acetal

Base Information

Chemical Name:(S)-2-(tert-Butyldiphenylsilyloxy)-3-<<2-(1H-indol-3-yl)ethyl>aminooxy>methylthiol-propanal diethyl acetal
CAS No.:162893-13-2
Molecular Formula:C₃₄H₄₆N₂O₄SSi
Molecular Weight:606.902
Hs Code.:

Synonyms:(S)-2-(tert-Butyldiphenylsilyloxy)-3-<<2-(1H-indol-3-yl)ethyl>aminooxy>methylthiol-propanal diethyl acetal

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Chemical Property of (S)-2-(tert-Butyldiphenylsilyloxy)-3-<<2-(1H-indol-3-yl)ethyl>aminooxy>methylthiol-propanal diethyl acetal

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Technology Process of (S)-2-(tert-Butyldiphenylsilyloxy)-3-<<2-(1H-indol-3-yl)ethyl>aminooxy>methylthiol-propanal diethyl acetal

There total 8 articles about (S)-2-(tert-Butyldiphenylsilyloxy)-3-<<2-(1H-indol-3-yl)ethyl>aminooxy>methylthiol-propanal diethyl acetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 162893-25-6
C₃₈H₅₀N₂O₆SSi

: 162893-13-2
(S)-2-(tert-Butyldiphenylsilyloxy)-3-<<2-(1H-indol-3-yl)ethyl>aminooxy>methylthiol-propanal diethyl acetal

Guidance literature:: With palladium diacetate; triethylammonium formate; triphenylphosphine; In acetonitrile; for 0.75h; Heating;
DOI:10.1002/recl.19951140107

Reference yield:

: 162893-08-5
(S)-2-Hydroxy-3-(p-tolylsulfonyloxy)propanal diethyl acetal

: 162893-13-2
(S)-2-(tert-Butyldiphenylsilyloxy)-3-<<2-(1H-indol-3-yl)ethyl>aminooxy>methylthiol-propanal diethyl acetal

Guidance literature:: Multi-step reaction with 6 steps

1: 94 percent / imidazole / dimethylformamide / Ambient temperature

2: 70 percent / dimethylformamide

3: 70 percent / NaOMe / methanol

4: 97 percent / KOH / Et₃BnNCl

5: 83 percent / NaH, NaI / 1,2-dimethoxy-ethane / 1.) 30 min, 2.) r.t., 1 h

6: 78 percent / aq. triethylammonium formate, Pd(OAc)2, Ph₃P / acetonitrile / 0.75 h / Heating

With 1H-imidazole; palladium diacetate; potassium hydroxide; sodium methylate; sodium hydride; triethylammonium formate; triphenylphosphine; sodium iodide; N-benzyl-N,N,N-triethylammonium chloride; In methanol; 1,2-dimethoxyethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/recl.19951140107

Reference yield:

: (R)-2-(tert-Butyl-diphenyl-silanyloxy)-3,3-diethoxy-propane-1-thiol

: 162893-13-2
(S)-2-(tert-Butyldiphenylsilyloxy)-3-<<2-(1H-indol-3-yl)ethyl>aminooxy>methylthiol-propanal diethyl acetal

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / KOH / Et₃BnNCl

2: 83 percent / NaH, NaI / 1,2-dimethoxy-ethane / 1.) 30 min, 2.) r.t., 1 h

3: 78 percent / aq. triethylammonium formate, Pd(OAc)2, Ph₃P / acetonitrile / 0.75 h / Heating

With palladium diacetate; potassium hydroxide; sodium hydride; triethylammonium formate; triphenylphosphine; sodium iodide; N-benzyl-N,N,N-triethylammonium chloride; In 1,2-dimethoxyethane; acetonitrile;
DOI:10.1002/recl.19951140107