(2R,3S)-2-methyl-2,3-dihydro-[1,4]oxazine-3,4-dicarboxylic acid 4-benzyl ester 3-methyl ester

Base Information

Chemical Name:(2R,3S)-2-methyl-2,3-dihydro-[1,4]oxazine-3,4-dicarboxylic acid 4-benzyl ester 3-methyl ester
CAS No.:1073249-72-5
Molecular Formula:C₁₅H₁₇NO₅
Molecular Weight:291.304
Hs Code.:

Synonyms:(2R,3S)-2-methyl-2,3-dihydro-[1,4]oxazine-3,4-dicarboxylic acid 4-benzyl ester 3-methyl ester

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Chemical Property of (2R,3S)-2-methyl-2,3-dihydro-[1,4]oxazine-3,4-dicarboxylic acid 4-benzyl ester 3-methyl ester

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Technology Process of (2R,3S)-2-methyl-2,3-dihydro-[1,4]oxazine-3,4-dicarboxylic acid 4-benzyl ester 3-methyl ester

There total 3 articles about (2R,3S)-2-methyl-2,3-dihydro-[1,4]oxazine-3,4-dicarboxylic acid 4-benzyl ester 3-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1073249-63-4
(2R,3S)-6-methoxy-2-methylmorpholine-3,4-dicarboxylic acid 4-benzyl ester 3-methyl ester

: 1073249-72-5
(2R,3S)-2-methyl-2,3-dihydro-[1,4]oxazine-3,4-dicarboxylic acid 4-benzyl ester 3-methyl ester

Guidance literature:: With toluene-4-sulfonic acid; for 2h; Heating / reflux;

Reference yield:

: 127680-34-6
O³-<(tert-butyl)dimethylsilyl>-L-threonine methyl ester

: 1073249-72-5
(2R,3S)-2-methyl-2,3-dihydro-[1,4]oxazine-3,4-dicarboxylic acid 4-benzyl ester 3-methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogen / palladium 10% on activated carbon / methanol; water / 20 °C

2: thionyl chloride / methanol / 4 h / 0 °C / Heating / reflux

3: sodium hydrogencarbonate / 1,4-dioxane; water / 16 h

4: toluene-4-sulfonic acid / 2 h / Heating / reflux

With thionyl chloride; hydrogen; sodium hydrogencarbonate; toluene-4-sulfonic acid; palladium 10% on activated carbon; In 1,4-dioxane; methanol; water;

Reference yield:

: 1073249-61-2
(2R,3S)-6-methoxy-2-methylmorpholine-3-carboxylic acid methyl ester

: 1073249-72-5
(2R,3S)-2-methyl-2,3-dihydro-[1,4]oxazine-3,4-dicarboxylic acid 4-benzyl ester 3-methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / 1,4-dioxane; water / 16 h

2: toluene-4-sulfonic acid / 2 h / Heating / reflux

With sodium hydrogencarbonate; toluene-4-sulfonic acid; In 1,4-dioxane; water;