N-[1-(4-carbamimidoyl-benzyl)-2-oxo-2-piperidin-1-yl-ethyl]-2-(naphthalene-2-sulfonylamino)-3-(pyridin-2-yldisulfanyl)-propionamide

Base Information

Chemical Name:N-[1-(4-carbamimidoyl-benzyl)-2-oxo-2-piperidin-1-yl-ethyl]-2-(naphthalene-2-sulfonylamino)-3-(pyridin-2-yldisulfanyl)-propionamide
CAS No.:754964-10-8
Molecular Formula:C₃₃H₃₆N₆O₄S₃
Molecular Weight:676.885
Hs Code.:

<i>N</i>-[1-(4-carbamimidoyl-benzyl)-2-oxo-2-piperidin-1-yl-ethyl]-2-(naphthalene-2-sulfonylamino)-3-(pyridin-2-yldisulfanyl)-propionamide

Synonyms:N-[1-(4-carbamimidoyl-benzyl)-2-oxo-2-piperidin-1-yl-ethyl]-2-(naphthalene-2-sulfonylamino)-3-(pyridin-2-yldisulfanyl)-propionamide

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Chemical Property of N-[1-(4-carbamimidoyl-benzyl)-2-oxo-2-piperidin-1-yl-ethyl]-2-(naphthalene-2-sulfonylamino)-3-(pyridin-2-yldisulfanyl)-propionamide

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Technology Process of N-[1-(4-carbamimidoyl-benzyl)-2-oxo-2-piperidin-1-yl-ethyl]-2-(naphthalene-2-sulfonylamino)-3-(pyridin-2-yldisulfanyl)-propionamide

There total 5 articles about N-[1-(4-carbamimidoyl-benzyl)-2-oxo-2-piperidin-1-yl-ethyl]-2-(naphthalene-2-sulfonylamino)-3-(pyridin-2-yldisulfanyl)-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 244606-17-5
(R)-2-(Naphthalene-2-sulfonylamino)-3-(pyridin-2-yldisulfanyl)-propionic acid

: (D/L)-4-amidinophenylalanyl piperidine dihydrochloride

: 754964-10-8
N-[1-(4-carbamimidoyl-benzyl)-2-oxo-2-piperidin-1-yl-ethyl]-2-(naphthalene-2-sulfonylamino)-3-(pyridin-2-yldisulfanyl)-propionamide

Guidance literature:: With N-ethylmorpholine;; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; for 16h;
DOI:10.1016/S0960-894X(99)00320-0

Reference yield:

: 2127-03-9
2,2'-dipyridyldisulphide

: 754964-10-8
N-[1-(4-carbamimidoyl-benzyl)-2-oxo-2-piperidin-1-yl-ethyl]-2-(naphthalene-2-sulfonylamino)-3-(pyridin-2-yldisulfanyl)-propionamide

Guidance literature:: Multi-step reaction with 2 steps

1: 2 N aq. AcOH / propan-2-ol / 1 h

2: 70 percent / EDCi, HOBt, N-ethylmorpholine / dimethylformamide / 16 h

With N-ethylmorpholine;; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1016/S0960-894X(99)00320-0

Reference yield:

: 93-11-8
2-Naphthalenesulfonyl chloride

: 754964-10-8
N-[1-(4-carbamimidoyl-benzyl)-2-oxo-2-piperidin-1-yl-ethyl]-2-(naphthalene-2-sulfonylamino)-3-(pyridin-2-yldisulfanyl)-propionamide

Guidance literature:: Multi-step reaction with 4 steps

1: 76 percent / aq. Na₂CO₃ / dioxane / 1 h

2: TFA, triisopropylsilane / CH₂Cl₂ / 0.33 h

3: 2 N aq. AcOH / propan-2-ol / 1 h

4: 70 percent / EDCi, HOBt, N-ethylmorpholine / dimethylformamide / 16 h

With N-ethylmorpholine;; chlorotriisopropylsilane; sodium carbonate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1016/S0960-894X(99)00320-0