(+/-)-E-3-<3-(sec-butylamino)-1-propen-1-yl>-2-ethoxycarbonyl-4-phenylquinoline

Base Information

• Chemical Name: (+/-)-E-3-<3-(sec-butylamino)-1-propen-1-yl>-2-ethoxycarbonyl-4-phenylquinoline
• CAS No.: 756792-11-7
• Molecular Formula: C₂₅H₂₈N₂O₂
• Molecular Weight: 388.51
• Mol file: 756792-11-7.mol

Synonyms:(+/-)-E-3-<3-(sec-butylamino)-1-propen-1-yl>-2-ethoxycarbonyl-4-phenylquinoline

Chemical Property of (+/-)-E-3-<3-(sec-butylamino)-1-propen-1-yl>-2-ethoxycarbonyl-4-phenylquinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (+/-)-E-3-<3-(sec-butylamino)-1-propen-1-yl>-2-ethoxycarbonyl-4-phenylquinoline

There total 4 articles about (+/-)-E-3-<3-(sec-butylamino)-1-propen-1-yl>-2-ethoxycarbonyl-4-phenylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-bromomethyl-2-ethoxycarbonyl-4-phenylquinoline (154419-41-7) → (+/-)-E-3-<3-(sec-butylamino)-1-propen-1-yl>-2-ethoxycarbonyl-4-phenylquinoline (756792-11-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 86 percent / benzene / 6 h / Heating

2: t-BuOK / benzene / 0.5 h / Ambient temperature

3: 2.) NBS, dibenzoyl peroxide / 1.) C₆H₆, reflux, 6 h, 2.) CCl₄, reflux, 2 h

4: ethanol / 0.5 h / Heating

With N-Bromosuccinimide; potassium tert-butylate; dibenzoyl peroxide; In ethanol; benzene;

DOI:10.3987/COM-93-6662

Reference yield:

4-Phenyl-3-[(triphenyl-λ5-phosphanylidene)-methyl]-quinoline-2-carboxylic acid ethyl ester → (+/-)-E-3-<3-(sec-butylamino)-1-propen-1-yl>-2-ethoxycarbonyl-4-phenylquinoline (756792-11-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 2.) NBS, dibenzoyl peroxide / 1.) C₆H₆, reflux, 6 h, 2.) CCl₄, reflux, 2 h

2: ethanol / 0.5 h / Heating

With N-Bromosuccinimide; dibenzoyl peroxide; In ethanol;

DOI:10.3987/COM-93-6662

Reference yield:

<(2-ethoxycarbonyl-4-phenylquinolin-3-yl)methyl>triphenylphosphonium bromide → (+/-)-E-3-<3-(sec-butylamino)-1-propen-1-yl>-2-ethoxycarbonyl-4-phenylquinoline (756792-11-7)

Guidance literature:

Multi-step reaction with 3 steps

1: t-BuOK / benzene / 0.5 h / Ambient temperature

2: 2.) NBS, dibenzoyl peroxide / 1.) C₆H₆, reflux, 6 h, 2.) CCl₄, reflux, 2 h

3: ethanol / 0.5 h / Heating

With N-Bromosuccinimide; potassium tert-butylate; dibenzoyl peroxide; In ethanol; benzene;

DOI:10.3987/COM-93-6662

upstream raw materials:

SEC-BUTYLAMINE

E-3-(3-bromo-1-propen-1-yl)-2-ethoxycarbonyl-4-phenylquinoline

3-bromomethyl-2-ethoxycarbonyl-4-phenylquinoline

Downstream raw materials:

(+/-)-3-<3-(sec-butylamino)prop-1-yl>-2-ethoxycarbonyl-4-phenylquinoline