N-(5H,11H-pyrrolo<2,1-c><1,4>benzoxazepin-3-ylmethylene)benzeneethanamine

Base Information

Chemical Name:N-(5H,11H-pyrrolo<2,1-c><1,4>benzoxazepin-3-ylmethylene)benzeneethanamine
CAS No.:64630-55-3
Molecular Formula:C₂₁H₂₀N₂O
Molecular Weight:316.403
Hs Code.:

Synonyms:N-(5H,11H-pyrrolo<2,1-c><1,4>benzoxazepin-3-ylmethylene)benzeneethanamine

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Chemical Property of N-(5H,11H-pyrrolo<2,1-c><1,4>benzoxazepin-3-ylmethylene)benzeneethanamine

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Technology Process of N-(5H,11H-pyrrolo<2,1-c><1,4>benzoxazepin-3-ylmethylene)benzeneethanamine

There total 6 articles about N-(5H,11H-pyrrolo<2,1-c><1,4>benzoxazepin-3-ylmethylene)benzeneethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 64630-50-8
5H,11H-pyrrolo<2,1-c><1,4>benzoxazepine-3-carboxaldehyde

: 64-04-0
phenethylamine

: 64630-55-3
N-(5H,11H-pyrrolo<2,1-c><1,4>benzoxazepin-3-ylmethylene)benzeneethanamine

Guidance literature:: With 3 A molecular sieve; In cyclohexane; benzene; at 80 ℃; for 48h;
DOI:10.1002/jhet.5570220429

Reference yield:

: 64630-49-5
5H,11H-pyrrolo<2,1-c><1,4>benzoxazepine

: 64630-55-3
N-(5H,11H-pyrrolo<2,1-c><1,4>benzoxazepin-3-ylmethylene)benzeneethanamine

Guidance literature:: Multi-step reaction with 2 steps

1: 1) POCl₃ / 1) room temp., 15 min; 2) 1,2-dichloroethane, reflux, 3 h

2: 60 percent / molecular sieves (3A) / benzene; cyclohexane / 48 h / 80 °C

With 3 A molecular sieve; trichlorophosphate; In cyclohexane; benzene;
DOI:10.1002/jhet.5570220429

Reference yield:

: 63880-57-9
1-[(2-fluorophenyl)methyl]pyrrole-2-carboxaldehyde

: 64630-55-3
N-(5H,11H-pyrrolo<2,1-c><1,4>benzoxazepin-3-ylmethylene)benzeneethanamine

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / NaBH₄ / propan-2-ol / 20 h / 80 °C

2: 7 g / NaH / 1) benzene, reflux, 1 h; 2) DMF, 80 deg C, 6 h

3: 1) POCl₃ / 1) room temp., 15 min; 2) 1,2-dichloroethane, reflux, 3 h

4: 60 percent / molecular sieves (3A) / benzene; cyclohexane / 48 h / 80 °C

With sodium tetrahydroborate; 3 A molecular sieve; sodium hydride; trichlorophosphate; In cyclohexane; isopropyl alcohol; benzene;
DOI:10.1002/jhet.5570220429