6-fluoro-2-{4-[(methoxycarbonyl-methyl-amino)-methyl]-phenyl}-3-(2-nitro-ethyl)-1H-indole-4-carboxylic acid methyl ester

Base Information

• Chemical Name: 6-fluoro-2-{4-[(methoxycarbonyl-methyl-amino)-methyl]-phenyl}-3-(2-nitro-ethyl)-1H-indole-4-carboxylic acid methyl ester
• CAS No.: 880160-68-9
• Molecular Formula: C₂₂H₂₂FN₃O₆
• Molecular Weight: 443.432
• Mol file: 880160-68-9.mol

Synonyms:6-fluoro-2-{4-[(methoxycarbonyl-methyl-amino)-methyl]-phenyl}-3-(2-nitro-ethyl)-1H-indole-4-carboxylic acid methyl ester

Chemical Property of 6-fluoro-2-{4-[(methoxycarbonyl-methyl-amino)-methyl]-phenyl}-3-(2-nitro-ethyl)-1H-indole-4-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

95%-98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-fluoro-2-{4-[(methoxycarbonyl-methyl-amino)-methyl]-phenyl}-3-(2-nitro-ethyl)-1H-indole-4-carboxylic acid methyl ester

There total 1 articles about 6-fluoro-2-{4-[(methoxycarbonyl-methyl-amino)-methyl]-phenyl}-3-(2-nitro-ethyl)-1H-indole-4-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

6-fluoro-2-{4-[(methoxycarbonyl-methylamino)-methyl]-phenyl}-3-((E)-2-nitro-vinyl)-1H-indole-4-carboxylic acid methyl ester (880160-67-8) → 6-fluoro-2-{4-[(methoxycarbonyl-methyl-amino)-methyl]-phenyl}-3-(2-nitro-ethyl)-1H-indole-4-carboxylic acid methyl ester (880160-68-9)

Guidance literature:

6-fluoro-2-{4-[(methoxycarbonyl-methylamino)-methyl]-phenyl}-3-((E)-2-nitro-vinyl)-1H-indole-4-carboxylic acid methyl ester; With sodium tetrahydroborate; In methanol; ethanol; at 15 ℃; for 1h;

With water; acetic acid; In methanol; ethanol;

Reference yield: 96.0%

6-fluoro-2-{4-[(methoxycarbonyl-methyl-amino)-methyl]-phenyl}-3-(2-nitro-ethyl)-1H-indole-4-carboxylic acid methyl ester (880160-68-9) → [4-(8-fluoro-6-oxo-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd]indol-2-yl)-benzyl]-methyl-carbamic acid methyl ester (880160-69-0)

Guidance literature:

6-fluoro-2-{4-[(methoxycarbonyl-methyl-amino)-methyl]-phenyl}-3-(2-nitro-ethyl)-1H-indole-4-carboxylic acid methyl ester; With hydrogen; acetic acid; Raney nickel; at 20 - 25 ℃; for 20 - 24h; under 7757.43 Torr;

With ammonia; water; In methanol; at 45 - 50 ℃; for 8h; pH=~ 10;

Reference yield:

6-fluoro-2-{4-[(methoxycarbonyl-methyl-amino)-methyl]-phenyl}-3-(2-nitro-ethyl)-1H-indole-4-carboxylic acid methyl ester (880160-68-9) → [4-(8-fluoro-6-oxo-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd]indol-2-yl)-benzyl]-methyl-carbamic acid methyl ester (880160-69-0) + C21H20FN3O4

Guidance literature:

With hydrogen; palladium over charcoal; Product distribution / selectivity;

upstream raw materials:

6-fluoro-2-{4-[(methoxycarbonyl-methylamino)-methyl]-phenyl}-3-((E)-2-nitro-vinyl)-1H-indole-4-carboxylic acid methyl ester

Downstream raw materials:

[4-(8-fluoro-6-oxo-3,4,5,6-tetrahydro-1H-azepino[5,4,3-cd]indol-2-yl)-benzyl]-methyl-carbamic acid methyl ester