3-(4-methoxyphenyl)-1-methyl-7-(pyridin-4-yl)-1,6-naphthyridin-2(1H)-one

Base Information

Chemical Name:3-(4-methoxyphenyl)-1-methyl-7-(pyridin-4-yl)-1,6-naphthyridin-2(1H)-one
CAS No.:1609102-25-1
Molecular Formula:C₂₁H₁₇N₃O₂
Molecular Weight:343.385
Hs Code.:

Synonyms:3-(4-methoxyphenyl)-1-methyl-7-(pyridin-4-yl)-1,6-naphthyridin-2(1H)-one

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Chemical Property of 3-(4-methoxyphenyl)-1-methyl-7-(pyridin-4-yl)-1,6-naphthyridin-2(1H)-one

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Technology Process of 3-(4-methoxyphenyl)-1-methyl-7-(pyridin-4-yl)-1,6-naphthyridin-2(1H)-one

There total 4 articles about 3-(4-methoxyphenyl)-1-methyl-7-(pyridin-4-yl)-1,6-naphthyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1609102-15-9
7-chloro-3-(4-methoxyphenyl)-1-methyl-1,6-naphthyridin-2(1H)-one

: 181219-01-2
4-pyridineboronic acid pinacol ester

: 1609102-25-1
3-(4-methoxyphenyl)-1-methyl-7-(pyridin-4-yl)-1,6-naphthyridin-2(1H)-one

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,4-dioxane; water; at 105 ℃; for 1h; Sealed tube; Microwave irradiation;
DOI:10.1002/ejoc.201301631

Reference yield:

: 449811-29-4
6-chloro-4-(methylamino)pyridine-3-carbaldehyde

: 1609102-25-1
3-(4-methoxyphenyl)-1-methyl-7-(pyridin-4-yl)-1,6-naphthyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 4 steps

1: piperidine; acetic acid / ethanol / 2.33 h / 20 °C / Reflux

2: N-iodo-succinimide; lithium acetate / water; N,N-dimethyl-formamide / 0.17 h / 110 °C / Microwave irradiation; Sealed tube

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; 1,4-dioxane / 2 h / 105 °C / Sealed tube

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; 1,4-dioxane / 1 h / 105 °C / Sealed tube; Microwave irradiation

With piperidine; N-iodo-succinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; lithium acetate; sodium carbonate; acetic acid; In 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; 3: |Suzuki-Miyaura Coupling / 4: |Suzuki-Miyaura Coupling;
DOI:10.1002/ejoc.201301631

Reference yield:

: 1609102-13-7
3-bromo-7-chloro-1-methyl-1,6-naphthyridin-2(1H)-one

: 1609102-25-1
3-(4-methoxyphenyl)-1-methyl-7-(pyridin-4-yl)-1,6-naphthyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; 1,4-dioxane / 2 h / 105 °C / Sealed tube

2: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / water; 1,4-dioxane / 1 h / 105 °C / Sealed tube; Microwave irradiation

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,4-dioxane; water; 1: |Suzuki-Miyaura Coupling / 2: |Suzuki-Miyaura Coupling;
DOI:10.1002/ejoc.201301631