3-O-[(trifluoromethylsulfonyl)oxy]-17α-benzyl-17β-trifluoroacetyloxyestra-1,3,5-(10)-triene

Base Information

• Chemical Name: 3-O-[(trifluoromethylsulfonyl)oxy]-17α-benzyl-17β-trifluoroacetyloxyestra-1,3,5-(10)-triene
• CAS No.: 915970-61-5
• Molecular Formula: C₂₈H₂₈F₆O₅S
• Molecular Weight: 590.584
• Mol file: 915970-61-5.mol

Synonyms:3-O-[(trifluoromethylsulfonyl)oxy]-17α-benzyl-17β-trifluoroacetyloxyestra-1,3,5-(10)-triene

Chemical Property of 3-O-[(trifluoromethylsulfonyl)oxy]-17α-benzyl-17β-trifluoroacetyloxyestra-1,3,5-(10)-triene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-O-[(trifluoromethylsulfonyl)oxy]-17α-benzyl-17β-trifluoroacetyloxyestra-1,3,5-(10)-triene

There total 3 articles about 3-O-[(trifluoromethylsulfonyl)oxy]-17α-benzyl-17β-trifluoroacetyloxyestra-1,3,5-(10)-triene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

C25H28O2(CF3CO)H + trifluoromethylsulfonic anhydride (358-23-6) → 3-O-[(trifluoromethylsulfonyl)oxy]-17α-benzyl-17β-trifluoroacetyloxyestra-1,3,5-(10)-triene (915970-61-5)

Guidance literature:

With dmap; In dichloromethane; at 0 ℃; for 1h;

DOI:10.1016/j.bmc.2006.08.033

Reference yield:

C25H28O2(CF3CO)2 → 3-O-[(trifluoromethylsulfonyl)oxy]-17α-benzyl-17β-trifluoroacetyloxyestra-1,3,5-(10)-triene (915970-61-5)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrochloric acid / methanol; ethyl acetate / 1 h / 20 °C

2: 67 percent / N,N-(dimethylamino)pyridine / CH₂Cl₂ / 1 h / 0 °C

With hydrogenchloride; dmap; In methanol; dichloromethane; ethyl acetate;

DOI:10.1016/j.bmc.2006.08.033

Reference yield:

17alpha-Benzylestradiol (3262-23-5) → 3-O-[(trifluoromethylsulfonyl)oxy]-17α-benzyl-17β-trifluoroacetyloxyestra-1,3,5-(10)-triene (915970-61-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 4-(dimethylamino)pyridine / CH₂Cl₂ / 7 h / 20 °C

2: hydrochloric acid / methanol; ethyl acetate / 1 h / 20 °C

3: 67 percent / N,N-(dimethylamino)pyridine / CH₂Cl₂ / 1 h / 0 °C

With hydrogenchloride; dmap; In methanol; dichloromethane; ethyl acetate;

DOI:10.1016/j.bmc.2006.08.033

upstream raw materials:

trifluoromethylsulfonic anhydride

17alpha-Benzylestradiol

Downstream raw materials:

3-O-pinacolatoboro-17α-benzyl-17β-trifluoroacetyloxyestra-1,3,5-(10)-triene

3-O-pinacolatoboro-17α-benzyl-17β-hydroxyestra-1,3,5-(10)-triene