2-Amino-N-[3-(3-bromo-2-methyl-imidazo[1,2-a]pyridin-8-yloxymethyl)-2,4-dichloro-phenyl]-N-methyl-propionamide

Base Information

Chemical Name:2-Amino-N-[3-(3-bromo-2-methyl-imidazo[1,2-a]pyridin-8-yloxymethyl)-2,4-dichloro-phenyl]-N-methyl-propionamide
CAS No.:160642-48-8
Molecular Formula:C₁₉H₁₉BrCl₂N₄O₂
Molecular Weight:486.195
Hs Code.:

Synonyms:2-Amino-N-[3-(3-bromo-2-methyl-imidazo[1,2-a]pyridin-8-yloxymethyl)-2,4-dichloro-phenyl]-N-methyl-propionamide

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Chemical Property of 2-Amino-N-[3-(3-bromo-2-methyl-imidazo[1,2-a]pyridin-8-yloxymethyl)-2,4-dichloro-phenyl]-N-methyl-propionamide

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Technology Process of 2-Amino-N-[3-(3-bromo-2-methyl-imidazo[1,2-a]pyridin-8-yloxymethyl)-2,4-dichloro-phenyl]-N-methyl-propionamide

There total 8 articles about 2-Amino-N-[3-(3-bromo-2-methyl-imidazo[1,2-a]pyridin-8-yloxymethyl)-2,4-dichloro-phenyl]-N-methyl-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 160642-35-3
3-Bromo-8-[2,6-dichloro-3-[N-methyl-N-(2-phthalimidopropionyl)-amino]benzyloxy]-2-methylimidazo[1,2-a]pyridine

: 160642-48-8
2-Amino-N-[3-(3-bromo-2-methyl-imidazo[1,2-a]pyridin-8-yloxymethyl)-2,4-dichloro-phenyl]-N-methyl-propionamide

Guidance literature:: With hydrazine hydrate; In ethanol; for 1h; Heating;
DOI:10.1021/jm970591c

Reference yield:

: 5866-97-7
2,6-dichloro-3-nitrobenzaldehyde

: 160642-48-8
2-Amino-N-[3-(3-bromo-2-methyl-imidazo[1,2-a]pyridin-8-yloxymethyl)-2,4-dichloro-phenyl]-N-methyl-propionamide

Guidance literature:: Multi-step reaction with 8 steps

1: 92.9 percent / NaBH₄ / methanol / 1 h / 10 °C

2: Et₃N / CH₂Cl₂

3: 95.1 percent / K₂CO₃ / dimethylformamide / 2 h / Ambient temperature

4: 95.1 percent / N-bromosuccinimide / ethanol

5: 77.2 percent / Fe, HCl / methanol / 0.5 h / Heating

6: 4-(dimethylamino)pyridine, pyridine, N-methylpyrrolidine / 2 h / 50 °C

7: 1.) NaH / 1.) DMF, RT, 30 min, 2.) DMF, RT, 30 min

8: H₂NNH₂*H₂O / ethanol / 1 h / Heating

With 1-Methylpyrrolidine; pyridine; hydrogenchloride; dmap; sodium tetrahydroborate; N-Bromosuccinimide; iron; sodium hydride; potassium carbonate; hydrazine hydrate; triethylamine; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm970591c

Reference yield:

: 160647-01-8
2,6-Dichloro-3-nitrobenzyl alcohol

: 160642-48-8
2-Amino-N-[3-(3-bromo-2-methyl-imidazo[1,2-a]pyridin-8-yloxymethyl)-2,4-dichloro-phenyl]-N-methyl-propionamide

Guidance literature:: Multi-step reaction with 7 steps

1: Et₃N / CH₂Cl₂

2: 95.1 percent / K₂CO₃ / dimethylformamide / 2 h / Ambient temperature

3: 95.1 percent / N-bromosuccinimide / ethanol

4: 77.2 percent / Fe, HCl / methanol / 0.5 h / Heating

5: 4-(dimethylamino)pyridine, pyridine, N-methylpyrrolidine / 2 h / 50 °C

6: 1.) NaH / 1.) DMF, RT, 30 min, 2.) DMF, RT, 30 min

7: H₂NNH₂*H₂O / ethanol / 1 h / Heating

With 1-Methylpyrrolidine; pyridine; hydrogenchloride; dmap; N-Bromosuccinimide; iron; sodium hydride; potassium carbonate; hydrazine hydrate; triethylamine; In methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm970591c