ethyl (3S,4S)-3-hydroxy-4-[(S)-3-methyl-2-(picolinamido)butanamido]-5-phenylpentanoic acid

Base Information

• Chemical Name: ethyl (3S,4S)-3-hydroxy-4-[(S)-3-methyl-2-(picolinamido)butanamido]-5-phenylpentanoic acid
• CAS No.: 1227870-47-4
• Molecular Formula: C₂₄H₃₁N₃O₅
• Molecular Weight: 441.527
• Mol file: 1227870-47-4.mol

Synonyms:ethyl (3S,4S)-3-hydroxy-4-[(S)-3-methyl-2-(picolinamido)butanamido]-5-phenylpentanoic acid

Chemical Property of ethyl (3S,4S)-3-hydroxy-4-[(S)-3-methyl-2-(picolinamido)butanamido]-5-phenylpentanoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl (3S,4S)-3-hydroxy-4-[(S)-3-methyl-2-(picolinamido)butanamido]-5-phenylpentanoic acid

There total 1 articles about ethyl (3S,4S)-3-hydroxy-4-[(S)-3-methyl-2-(picolinamido)butanamido]-5-phenylpentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.3%

ethyl (3S,4S)-3-hydroxy-4-amino-5-phenylpentanoate hydrochloride (120742-17-8) + (S)-3-methyl-2-[(1-pyridin-2-ylmethanoyl)amino]butyric acid (724733-75-9) → ethyl (3S,4S)-3-hydroxy-4-[(S)-3-methyl-2-(picolinamido)butanamido]-5-phenylpentanoic acid (1227870-47-4)

Guidance literature:

(S)-3-methyl-2-[(1-pyridin-2-ylmethanoyl)amino]butyric acid; With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide; at 0 ℃;

With 4-methyl-morpholine; In N,N-dimethyl-formamide; at 0 ℃;

ethyl (3S,4S)-3-hydroxy-4-amino-5-phenylpentanoate hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 8h;

DOI:10.1021/jm100233b

Reference yield: 94.7%

ethyl (3S,4S)-3-hydroxy-4-[(S)-3-methyl-2-(picolinamido)butanamido]-5-phenylpentanoic acid (1227870-47-4) → (3S,4S)-3-hydroxy-4-[(S)-3-methyl-2-(picolinamido)butanamido]-5-phenylpentanoic acid (1227870-48-5)

Guidance literature:

With water; sodium hydroxide; In 1,4-dioxane; at 0 - 20 ℃;

DOI:10.1021/jm100233b

upstream raw materials:

ethyl (3S,4S)-3-hydroxy-4-amino-5-phenylpentanoate hydrochloride

(S)-3-methyl-2-[(1-pyridin-2-ylmethanoyl)amino]butyric acid

Downstream raw materials:

(3S,4S)-3-hydroxy-4-[(S)-3-methyl-2-(picolinamido)butanamido]-5-phenylpentanoic acid