t-butyl trans-(2-diphenylphosphinyl)cyclobutylacetate

Base Information

• Chemical Name: t-butyl trans-(2-diphenylphosphinyl)cyclobutylacetate
• CAS No.: 137134-33-9
• Molecular Formula: C₂₂H₂₇O₃P
• Molecular Weight: 370.428
• Mol file: 137134-33-9.mol

Synonyms:t-butyl trans-(2-diphenylphosphinyl)cyclobutylacetate

Chemical Property of t-butyl trans-(2-diphenylphosphinyl)cyclobutylacetate

Chemical Property:

Purity/Quality:

Safty Information:

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• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of t-butyl trans-(2-diphenylphosphinyl)cyclobutylacetate

There total 1 articles about t-butyl trans-(2-diphenylphosphinyl)cyclobutylacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

acetic acid tert-butyl ester (540-88-5) + (1-cyclobutenyl)diphenylphosphine oxide (86046-76-6) → t-butyl trans-(2-diphenylphosphinyl)cyclobutylacetate (137134-33-9)

Guidance literature:

With lithium diisopropyl amide; Yield given. Multistep reaction; 1.) THF, -50 deg C, 0.5 h, 2.) THF, -50 deg C, 3 h;

DOI:10.1016/S0957-4166(00)86121-2

Reference yield: 76.0%

t-butyl trans-(2-diphenylphosphinyl)cyclobutylacetate (137134-33-9) → t-butyl trans-(2-diphenylphosphino)cyclobutylacetate (137134-35-1)

Guidance literature:

With trichlorosilane; In benzene; at 110 ℃; for 8h;

DOI:10.1016/S0957-4166(00)86121-2

Reference yield:

t-butyl trans-(2-diphenylphosphinyl)cyclobutylacetate (137134-33-9) → (+)-trans-(2-diphenylphosphino)cyclobutylacetic acid (137134-37-3,137134-43-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 76 percent / HSiCl₃ / benzene / 8 h / 110 °C

2: 96 percent / p-TsOH*H₂O / benzene / 3 h / Heating

With trichlorosilane; toluene-4-sulfonic acid; In benzene;

DOI:10.1016/S0957-4166(00)86121-2

upstream raw materials:

acetic acid tert-butyl ester

(1-cyclobutenyl)diphenylphosphine oxide

Downstream raw materials:

t-butyl trans-(2-diphenylphosphino)cyclobutylacetate

(+)-trans-(2-diphenylphosphino)cyclobutylacetic acid