5-ethyl-2-(3-fluoro-4-isopropoxyphenylamino)-3-(4-methylphenoxy)pyrazine

Base Information

Chemical Name:5-ethyl-2-(3-fluoro-4-isopropoxyphenylamino)-3-(4-methylphenoxy)pyrazine
CAS No.:1359815-46-5
Molecular Formula:C₂₂H₂₄FN₃O₂
Molecular Weight:381.45
Hs Code.:

Synonyms:5-ethyl-2-(3-fluoro-4-isopropoxyphenylamino)-3-(4-methylphenoxy)pyrazine

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Chemical Property of 5-ethyl-2-(3-fluoro-4-isopropoxyphenylamino)-3-(4-methylphenoxy)pyrazine

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Technology Process of 5-ethyl-2-(3-fluoro-4-isopropoxyphenylamino)-3-(4-methylphenoxy)pyrazine

There total 7 articles about 5-ethyl-2-(3-fluoro-4-isopropoxyphenylamino)-3-(4-methylphenoxy)pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 18.0%

: 202865-80-3
4-bromo-2-fluoro-1-isopropoxybenzene

: 1359818-31-7
2-amino-5-ethyl-3-(4-methylphenoxy)pyrazine

: 1359815-46-5
5-ethyl-2-(3-fluoro-4-isopropoxyphenylamino)-3-(4-methylphenoxy)pyrazine

Guidance literature:: With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium phenoxide; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; for 4h; Reflux;

Reference yield:

: 1359818-30-6
[5-ethyl-3-(4-methylphenoxy)pyrazine-2-yl]carbamic acid t-butylester

: 1359815-46-5
5-ethyl-2-(3-fluoro-4-isopropoxyphenylamino)-3-(4-methylphenoxy)pyrazine

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / chloroform / 4 h / 20 °C

2: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium phenoxide / 1,4-dioxane / 4 h / Reflux

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium phenoxide; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; In 1,4-dioxane; chloroform;

Reference yield:

: [5-bromo-3-(4-methylphenoxy)-pyrazine-2-yl]dicarbamic acid di-t-butylester

: 1359815-46-5
5-ethyl-2-(3-fluoro-4-isopropoxyphenylamino)-3-(4-methylphenoxy)pyrazine

Guidance literature:: Multi-step reaction with 4 steps

1: lithium chloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; N,N-dimethyl-formamide / 5 h / Reflux

2: hydrogen; 5%-palladium/activated carbon / methanol

3: trifluoroacetic acid / chloroform / 4 h / 20 °C

4: 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium phenoxide / 1,4-dioxane / 4 h / Reflux

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 5%-palladium/activated carbon; hydrogen; sodium phenoxide; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trifluoroacetic acid; lithium chloride; In tetrahydrofuran; 1,4-dioxane; methanol; chloroform; N,N-dimethyl-formamide;