(R)-3-methyl-2-(3-oxo-3,6-dihydro[1,2]oxazin-2-yl)-butyric acid benzhydryl ester

Base Information

Chemical Name:(R)-3-methyl-2-(3-oxo-3,6-dihydro[1,2]oxazin-2-yl)-butyric acid benzhydryl ester
CAS No.:494870-81-4
Molecular Formula:C₂₂H₂₃NO₄
Molecular Weight:365.429
Hs Code.:

Synonyms:(R)-3-methyl-2-(3-oxo-3,6-dihydro[1,2]oxazin-2-yl)-butyric acid benzhydryl ester

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Chemical Property of (R)-3-methyl-2-(3-oxo-3,6-dihydro[1,2]oxazin-2-yl)-butyric acid benzhydryl ester

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Technology Process of (R)-3-methyl-2-(3-oxo-3,6-dihydro[1,2]oxazin-2-yl)-butyric acid benzhydryl ester

There total 5 articles about (R)-3-methyl-2-(3-oxo-3,6-dihydro[1,2]oxazin-2-yl)-butyric acid benzhydryl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 494870-80-3
(R)-2-(N-acryloyl-N-allyloxyamino)-3-methylbutyric acid benzhydryl ester

: 494870-81-4
(R)-3-methyl-2-(3-oxo-3,6-dihydro[1,2]oxazin-2-yl)-butyric acid benzhydryl ester

Guidance literature:: Grubbs catalyst first generation; In dichloromethane; for 4h; Heating;
DOI:10.1139/v04-174

Reference yield:

: 494870-79-0
(R)-2-allyloxyamino-3-methylbutiryc acid benzhydryl ester

: 494870-81-4
(R)-3-methyl-2-(3-oxo-3,6-dihydro[1,2]oxazin-2-yl)-butyric acid benzhydryl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 81 percent / triethylamine / CH₂Cl₂ / 0 - 20 °C

2: 90 percent / bis(tricyclohexylphosphine)benzylideneruthenium dichloride / CH₂Cl₂ / 4 h / Heating

With triethylamine; Grubbs catalyst first generation; In dichloromethane; 2: ring-closing metathesis;
DOI:10.1139/v04-174

Reference yield:

: 17407-55-5
(S)-2-Hydroxy-3-methylbutanoic acid

: 494870-81-4
(R)-3-methyl-2-(3-oxo-3,6-dihydro[1,2]oxazin-2-yl)-butyric acid benzhydryl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / ethyl acetate / 6 h / 20 °C

2: 89 percent / acetonitrile / 3 h / Heating

3: 81 percent / triethylamine / CH₂Cl₂ / 0 - 20 °C

4: 90 percent / bis(tricyclohexylphosphine)benzylideneruthenium dichloride / CH₂Cl₂ / 4 h / Heating

With triethylamine; Grubbs catalyst first generation; In dichloromethane; ethyl acetate; acetonitrile; 4: ring-closing metathesis;
DOI:10.1139/v04-174