N,N'-(2-nitrobenzenesulfonamide)-N,N'-[(tert-butoxycarbonyl)methyl]-1-(p-nitrobenzyl)-1,2-diaminoethane

Base Information

• Chemical Name: N,N'-(2-nitrobenzenesulfonamide)-N,N'-[(tert-butoxycarbonyl)methyl]-1-(p-nitrobenzyl)-1,2-diaminoethane
• CAS No.: 1450624-94-8
• Molecular Formula: C₃₃H₃₉N₅O₁₄S₂
• Molecular Weight: 793.83
• Mol file: 1450624-94-8.mol

Synonyms:N,N'-(2-nitrobenzenesulfonamide)-N,N'-[(tert-butoxycarbonyl)methyl]-1-(p-nitrobenzyl)-1,2-diaminoethane

Chemical Property of N,N'-(2-nitrobenzenesulfonamide)-N,N'-[(tert-butoxycarbonyl)methyl]-1-(p-nitrobenzyl)-1,2-diaminoethane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N,N'-(2-nitrobenzenesulfonamide)-N,N'-[(tert-butoxycarbonyl)methyl]-1-(p-nitrobenzyl)-1,2-diaminoethane

There total 3 articles about N,N'-(2-nitrobenzenesulfonamide)-N,N'-[(tert-butoxycarbonyl)methyl]-1-(p-nitrobenzyl)-1,2-diaminoethane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

bromoacetic acid tert-butyl ester (5292-43-3) + N,N′-(2-nitrobenzenesulfonamide)-1-(p-nitrobenzyl)-1,2-diaminoethane (1450624-93-7) → N,N'-(2-nitrobenzenesulfonamide)-N,N'-[(tert-butoxycarbonyl)methyl]-1-(p-nitrobenzyl)-1,2-diaminoethane (1450624-94-8)

Guidance literature:

With sodium carbonate; In N,N-dimethyl-formamide; at 50 ℃; for 24h; Molecular sieve;

DOI:10.1021/ja4049493

Reference yield:

2-Nitrobenzenesulfonyl chloride (1694-92-4) → N,N'-(2-nitrobenzenesulfonamide)-N,N'-[(tert-butoxycarbonyl)methyl]-1-(p-nitrobenzyl)-1,2-diaminoethane (1450624-94-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / tetrahydrofuran / 50 °C / Cooling with ice

2: sodium carbonate / N,N-dimethyl-formamide / 24 h / 50 °C / Molecular sieve

With sodium hydrogencarbonate; sodium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/ja4049493

Reference yield:

3-(4-Nitrophenyl)propane-1,2-diamine (81677-62-5) → N,N'-(2-nitrobenzenesulfonamide)-N,N'-[(tert-butoxycarbonyl)methyl]-1-(p-nitrobenzyl)-1,2-diaminoethane (1450624-94-8)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydrogencarbonate / tetrahydrofuran / 50 °C / Cooling with ice

2: sodium carbonate / N,N-dimethyl-formamide / 24 h / 50 °C / Molecular sieve

With sodium hydrogencarbonate; sodium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1021/ja4049493

upstream raw materials:

2-Nitrobenzenesulfonyl chloride

bromoacetic acid tert-butyl ester

N,N′-(2-nitrobenzenesulfonamide)-1-(p-nitrobenzyl)-1,2-diaminoethane

3-(4-Nitrophenyl)propane-1,2-diamine

Downstream raw materials:

N,N'[(tert-butoxycarbonyl)methyl]-1-(p-nitrobenzyl)-1,2-diaminoethane