(2R,4S)-5-(tert-Butyl-diphenyl-silanyloxy)-2,4-dimethyl-pentanoic acid methyl ester

Base Information

• Chemical Name: (2R,4S)-5-(tert-Butyl-diphenyl-silanyloxy)-2,4-dimethyl-pentanoic acid methyl ester
• CAS No.: 157837-63-3
• Molecular Formula: C₂₄H₃₄O₃Si
• Molecular Weight: 398.618

Synonyms:(2R,4S)-5-(tert-Butyl-diphenyl-silanyloxy)-2,4-dimethyl-pentanoic acid methyl ester

Chemical Property of (2R,4S)-5-(tert-Butyl-diphenyl-silanyloxy)-2,4-dimethyl-pentanoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,4S)-5-(tert-Butyl-diphenyl-silanyloxy)-2,4-dimethyl-pentanoic acid methyl ester

There total 2 articles about (2R,4S)-5-(tert-Butyl-diphenyl-silanyloxy)-2,4-dimethyl-pentanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

[2R,4S]-5-hydroxy-2,4-dimethyl-pentanoic acid methyl ester (82917-26-8) + tert-butylchlorodiphenylsilane (58479-61-1) → (2R,4S)-5-(tert-Butyl-diphenyl-silanyloxy)-2,4-dimethyl-pentanoic acid methyl ester (157837-63-3)

Guidance literature:

With 1H-imidazole;

DOI:10.1021/ja963066w

Reference yield:

2,4-dimethyl-pentanedioic acid dimethyl ester (4098-66-2,858371-81-0) → (2R,4S)-5-(tert-Butyl-diphenyl-silanyloxy)-2,4-dimethyl-pentanoic acid methyl ester (157837-63-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 88 percent / α-chymotripsin

2: 100 percent / BH₃*Me₂S

3: 93 percent / imidazole

With 1H-imidazole; dimethylsulfide borane complex; α-chymotripsin;

DOI:10.1021/ja963066w

Reference yield: 100.0%

(2R,4S)-5-(tert-Butyl-diphenyl-silanyloxy)-2,4-dimethyl-pentanoic acid methyl ester (157837-63-3) → (2R,4S)-5-{[tert-butyl(diphenyl)silyl]oxy}-2,4-dimethylpentan-1-ol (157837-64-4)

Guidance literature:

With diisobutylaluminium hydride;

DOI:10.1021/ja963066w

upstream raw materials:

[2R,4S]-5-hydroxy-2,4-dimethyl-pentanoic acid methyl ester

tert-butylchlorodiphenylsilane

2,4-dimethyl-pentanedioic acid dimethyl ester

Downstream raw materials:

(2R,4S)-5-{[tert-butyl(diphenyl)silyl]oxy}-2,4-dimethylpentan-1-ol

(2R,4S)-5-{[tert-butyl(diphenyl)silyl]oxy}-2,4-dimethylpentanal

tert-Butyl-((2S,4R)-4-[1,3]dithian-2-yl-2-methyl-pentyloxy)-diphenyl-silane

(E)-(2R,3S,6R,9S,12R,14S)-9-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-1-((1S,3R,4R)-3-methoxy-4-triisopropylsilanyloxy-cyclohexyl)-2,6,8,12,14-pentamethyl-hexadec-7-en-15-yne-5,11-dione

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 157837-63-3 (2R,4S)-5-(tert-Butyl-diphenyl-silanyloxy)-2,4-dimethyl-pentanoic acid methyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send