((2S,3S,4aR,8R,8aR)-2,3-dimethoxy-2,3-dimethyloctahydro-[1,4]dioxino[2,3-c]pyridin-8-yl)methanol hydrochloride

Base Information

Chemical Name:((2S,3S,4aR,8R,8aR)-2,3-dimethoxy-2,3-dimethyloctahydro-[1,4]dioxino[2,3-c]pyridin-8-yl)methanol hydrochloride
CAS No.:1293280-08-6
Molecular Formula:C₁₂H₂₃NO₅*ClH
Molecular Weight:297.779
Hs Code.:

Synonyms:((2S,3S,4aR,8R,8aR)-2,3-dimethoxy-2,3-dimethyloctahydro-[1,4]dioxino[2,3-c]pyridin-8-yl)methanol hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of ((2S,3S,4aR,8R,8aR)-2,3-dimethoxy-2,3-dimethyloctahydro-[1,4]dioxino[2,3-c]pyridin-8-yl)methanol hydrochloride

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Technology Process of ((2S,3S,4aR,8R,8aR)-2,3-dimethoxy-2,3-dimethyloctahydro-[1,4]dioxino[2,3-c]pyridin-8-yl)methanol hydrochloride

There total 1 articles about ((2S,3S,4aR,8R,8aR)-2,3-dimethoxy-2,3-dimethyloctahydro-[1,4]dioxino[2,3-c]pyridin-8-yl)methanol hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1084896-40-1
(2S,3S,4aS,5S,8R,8aR)-5-(benzyloxy)-2,3-dimethoxy-2,3-dimethylhexahydro-2H-pyrano[3,4-b][1,4]dioxine-8-carbonitrile

: 1293280-08-6
((2S,3S,4aR,8R,8aR)-2,3-dimethoxy-2,3-dimethyloctahydro-[1,4]dioxino[2,3-c]pyridin-8-yl)methanol hydrochloride

Guidance literature:: (2S,3S,4aS,5S,8R,8aR)-5-(benzyloxy)-2,3-dimethoxy-2,3-dimethylhexahydro-2H-pyrano[3,4-b][1,4]dioxine-8-carbonitrile; With ammonium formate; palladium(II) hydroxide; In methanol; at 50 - 55 ℃; for 24h;

With hydrogenchloride; In isopropyl alcohol; acetone; Cooling with ice;

Reference yield: 95.0%

: 1293280-08-6
((2S,3S,4aR,8R,8aR)-2,3-dimethoxy-2,3-dimethyloctahydro-[1,4]dioxino[2,3-c]pyridin-8-yl)methanol hydrochloride

: 100-44-7
benzyl chloride

: 1251455-39-6
((2S,3S,4aR,8R,8aR)-6-benzyl-2,3-dimethoxy-2,3-dimethyloctahydro-[1,4]dioxino[2,3-c]pyridine-8-yl)methanol

Guidance literature:: ((2S,3S,4aR,8R,8aR)-2,3-dimethoxy-2,3-dimethyloctahydro-[1,4]dioxino[2,3-c]pyridin-8-yl)methanol hydrochloride; With potassium carbonate; In N,N-dimethyl-formamide; at 40 ℃; for 4h;

benzyl chloride; In N,N-dimethyl-formamide; at 40 ℃;

Reference yield:

: 1293280-08-6
((2S,3S,4aR,8R,8aR)-2,3-dimethoxy-2,3-dimethyloctahydro-[1,4]dioxino[2,3-c]pyridin-8-yl)methanol hydrochloride

: 1293280-09-7
((2S,3S,4aR,8R,8aR)-6-benzyl-2,3-dimethoxy-2,3-dimethyloctahydro-[1,4]dioxino[2,3-c]pyridin-8-yl)carboxaldehyde

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 40 °C

1.2: 40 °C

2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 1.5 h / -78 °C

2.2: Cooling

With oxalyl dichloride; potassium carbonate; dimethyl sulfoxide; In dichloromethane; N,N-dimethyl-formamide; 2.1: Swern Oxidation / 2.2: Swern Oxidation;