5-{(S)-1-[4-(3-amino-1-propynyl)-5-methoxy-2-nitrophenyl]-2,2-dimethylpropyloxy}methyl-2‘-deoxycytidine-5’-α-thiotriphosphate

Base Information

Chemical Name:5-{(S)-1-[4-(3-amino-1-propynyl)-5-methoxy-2-nitrophenyl]-2,2-dimethylpropyloxy}methyl-2‘-deoxycytidine-5’-α-thiotriphosphate
CAS No.:1427311-81-6
Molecular Formula:C₂₅H₃₆N₅O₁₆P₃S
Molecular Weight:787.572
Hs Code.:

Synonyms:5-{(S)-1-[4-(3-amino-1-propynyl)-5-methoxy-2-nitrophenyl]-2,2-dimethylpropyloxy}methyl-2‘-deoxycytidine-5’-α-thiotriphosphate

Suppliers and Price of 5-{(S)-1-[4-(3-amino-1-propynyl)-5-methoxy-2-nitrophenyl]-2,2-dimethylpropyloxy}methyl-2‘-deoxycytidine-5’-α-thiotriphosphate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5-{(S)-1-[4-(3-amino-1-propynyl)-5-methoxy-2-nitrophenyl]-2,2-dimethylpropyloxy}methyl-2‘-deoxycytidine-5’-α-thiotriphosphate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 5-{(S)-1-[4-(3-amino-1-propynyl)-5-methoxy-2-nitrophenyl]-2,2-dimethylpropyloxy}methyl-2‘-deoxycytidine-5’-α-thiotriphosphate

There total 15 articles about 5-{(S)-1-[4-(3-amino-1-propynyl)-5-methoxy-2-nitrophenyl]-2,2-dimethylpropyloxy}methyl-2‘-deoxycytidine-5’-α-thiotriphosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₇H₃₅F₃N₅O₁₇P₃S

: 1427311-81-6
5-{(S)-1-[4-(3-amino-1-propynyl)-5-methoxy-2-nitrophenyl]-2,2-dimethylpropyloxy}methyl-2‘-deoxycytidine-5’-α-thiotriphosphate

Guidance literature:: With ammonium hydroxide; In water; at 20 ℃; for 1h;

Reference yield:

: 1028383-90-5
N³-tert-butyloxycarbonyl-5-bromomethyl-3',5'-bis-O-tert-butyldimethylsilyl-2'-deoxyuridine

: 1427311-81-6
5-{(S)-1-[4-(3-amino-1-propynyl)-5-methoxy-2-nitrophenyl]-2,2-dimethylpropyloxy}methyl-2‘-deoxycytidine-5’-α-thiotriphosphate

Guidance literature:: Multi-step reaction with 9 steps

1.1: 0.75 h / 110 °C / Inert atmosphere

2.1: ammonium fluoride / methanol / 12 h / 50 °C

3.1: 1H-imidazole / N,N-dimethyl-formamide / 12 h / 20 °C

4.1: dmap; triethylamine / dichloromethane / 20 °C / Inert atmosphere

5.1: ammonia / 1,4-dioxane / 90 °C / Sealed tube

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 20 °C

7.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide; triethylamine / N,N-dimethyl-formamide / 12 h / 50 °C

8.1: trichlorothiophosphine; triethyl phosphate; 2,6-dimethylpyridine / 1 h / 0 °C / Inert atmosphere

8.2: 0.03 h / 20 °C / Inert atmosphere

8.3: 3407 / 1 h / 20 °C / pH 7.5 / Inert atmosphere

9.1: ammonium hydroxide / water / 1 h / 20 °C

With 1H-imidazole; 2,6-dimethylpyridine; trichlorothiophosphine; dmap; ammonium fluoride; ammonium hydroxide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethyl phosphate; tetrabutyl ammonium fluoride; ammonia; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 766-85-8
3-methoxy-1-iodobenzene

: 1427311-81-6
5-{(S)-1-[4-(3-amino-1-propynyl)-5-methoxy-2-nitrophenyl]-2,2-dimethylpropyloxy}methyl-2‘-deoxycytidine-5’-α-thiotriphosphate

Guidance literature:: Multi-step reaction with 14 steps

1.1: sodium nitrite; acetic acid; nitric acid / 24 h / 20 °C

1.2: 60 °C

2.1: phenylmagnesium chloride / tetrahydrofuran / 2 h / -40 °C / Inert atmosphere

2.2: 3 h / -30 - 20 °C / Inert atmosphere

2.3: Inert atmosphere

3.1: dmap / dichloromethane / 20 °C / Inert atmosphere

4.1: ethanol / Reflux

5.1: potassium carbonate; methanol / 1 h / Reflux

6.1: 0.75 h / 110 °C / Inert atmosphere

7.1: ammonium fluoride / methanol / 12 h / 50 °C

8.1: 1H-imidazole / N,N-dimethyl-formamide / 12 h / 20 °C

9.1: dmap; triethylamine / dichloromethane / 20 °C / Inert atmosphere

10.1: ammonia / 1,4-dioxane / 90 °C / Sealed tube

11.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 20 °C

12.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide; triethylamine / N,N-dimethyl-formamide / 12 h / 50 °C

13.1: trichlorothiophosphine; triethyl phosphate; 2,6-dimethylpyridine / 1 h / 0 °C / Inert atmosphere

13.2: 0.03 h / 20 °C / Inert atmosphere

13.3: 3407 / 1 h / 20 °C / pH 7.5 / Inert atmosphere

14.1: ammonium hydroxide / water / 1 h / 20 °C

With 1H-imidazole; 2,6-dimethylpyridine; methanol; trichlorothiophosphine; dmap; ammonium fluoride; ammonium hydroxide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethyl phosphate; phenylmagnesium chloride; tetrabutyl ammonium fluoride; ammonia; nitric acid; potassium carbonate; acetic acid; triethylamine; sodium nitrite; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;