3'-dephenyl-3'-(2,2-difluorovinyl)-2-debenzoyl-2-(3-chlorobenzoyl)-10-cyclopropanecarbonyldocetaxel

Base Information

Chemical Name:3'-dephenyl-3'-(2,2-difluorovinyl)-2-debenzoyl-2-(3-chlorobenzoyl)-10-cyclopropanecarbonyldocetaxel
CAS No.:926306-85-6
Molecular Formula:C₄₃H₅₂ClF₂NO₁₅
Molecular Weight:896.333
Hs Code.:

Synonyms:3'-dephenyl-3'-(2,2-difluorovinyl)-2-debenzoyl-2-(3-chlorobenzoyl)-10-cyclopropanecarbonyldocetaxel

Suppliers and Price of 3'-dephenyl-3'-(2,2-difluorovinyl)-2-debenzoyl-2-(3-chlorobenzoyl)-10-cyclopropanecarbonyldocetaxel

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3'-dephenyl-3'-(2,2-difluorovinyl)-2-debenzoyl-2-(3-chlorobenzoyl)-10-cyclopropanecarbonyldocetaxel

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3'-dephenyl-3'-(2,2-difluorovinyl)-2-debenzoyl-2-(3-chlorobenzoyl)-10-cyclopropanecarbonyldocetaxel

There total 9 articles about 3'-dephenyl-3'-(2,2-difluorovinyl)-2-debenzoyl-2-(3-chlorobenzoyl)-10-cyclopropanecarbonyldocetaxel which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₅₈H₈₆ClF₂NO₁₅Si₂

: 926306-85-6
3'-dephenyl-3'-(2,2-difluorovinyl)-2-debenzoyl-2-(3-chlorobenzoyl)-10-cyclopropanecarbonyldocetaxel

Guidance literature:: With pyridine; hydrogen fluoride; In acetonitrile; at 0 - 20 ℃;
DOI:10.1016/j.jfluchem.2012.07.007

Reference yield:

: C₃₅H₄₉ClO₁₀Si

: 926306-85-6
3'-dephenyl-3'-(2,2-difluorovinyl)-2-debenzoyl-2-(3-chlorobenzoyl)-10-cyclopropanecarbonyldocetaxel

Guidance literature:: Multi-step reaction with 3 steps

1: lithium hexamethyldisilazane / tetrahydrofuran

2: lithium hexamethyldisilazane / tetrahydrofuran / -40 °C

3: pyridine; hydrogen fluoride / acetonitrile / 0 - 20 °C

With pyridine; hydrogen fluoride; lithium hexamethyldisilazane; In tetrahydrofuran; acetonitrile;
DOI:10.1016/j.jfluchem.2012.07.007

Reference yield:

: 926306-99-2
(3R,4S)-1-(4-methoxyphenyl)-3-triisopropylsiloxy-4-(2,2-difluorovinyl)azetidin-2-one

: 926306-85-6
3'-dephenyl-3'-(2,2-difluorovinyl)-2-debenzoyl-2-(3-chlorobenzoyl)-10-cyclopropanecarbonyldocetaxel

Guidance literature:: Multi-step reaction with 4 steps

1: ammonium cerium (IV) nitrate; water / acetonitrile / 2 h / -10 °C

2: triethylamine; dmap / dichloromethane / 18 h / 20 °C

3: lithium hexamethyldisilazane / tetrahydrofuran / -40 °C

4: pyridine; hydrogen fluoride / acetonitrile / 0 - 20 °C

With pyridine; dmap; ammonium cerium (IV) nitrate; hydrogen fluoride; water; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1016/j.jfluchem.2012.07.007