2-[(1-{4-[(3,5-dimethyl-phenylcarbamoyl)-methyl]-phenoxy}-cyclopentanecarbonyl)-amino]-pentanedioic acid 5-tert-butyl ester 1-methyl ester

Base Information

Chemical Name:2-[(1-{4-[(3,5-dimethyl-phenylcarbamoyl)-methyl]-phenoxy}-cyclopentanecarbonyl)-amino]-pentanedioic acid 5-tert-butyl ester 1-methyl ester
CAS No.:328236-10-8
Molecular Formula:C₃₂H₄₂N₂O₇
Molecular Weight:566.695
Hs Code.:

2-[(1-{4-[(3,5-dimethyl-phenylcarbamoyl)-methyl]-phenoxy}-cyclopentanecarbonyl)-amino]-pentanedioic acid 5-<i>tert</i>-butyl ester 1-methyl ester

Synonyms:2-[(1-{4-[(3,5-dimethyl-phenylcarbamoyl)-methyl]-phenoxy}-cyclopentanecarbonyl)-amino]-pentanedioic acid 5-tert-butyl ester 1-methyl ester

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Chemical Property of 2-[(1-{4-[(3,5-dimethyl-phenylcarbamoyl)-methyl]-phenoxy}-cyclopentanecarbonyl)-amino]-pentanedioic acid 5-tert-butyl ester 1-methyl ester

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Technology Process of 2-[(1-{4-[(3,5-dimethyl-phenylcarbamoyl)-methyl]-phenoxy}-cyclopentanecarbonyl)-amino]-pentanedioic acid 5-tert-butyl ester 1-methyl ester

There total 4 articles about 2-[(1-{4-[(3,5-dimethyl-phenylcarbamoyl)-methyl]-phenoxy}-cyclopentanecarbonyl)-amino]-pentanedioic acid 5-tert-butyl ester 1-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 6234-01-1,16948-36-0
L-glutamic acid 5-tert-butyl 1-methyl ester hydrochloride

: 170787-77-6
JP-7

: 328236-10-8
2-[(1-{4-[(3,5-dimethyl-phenylcarbamoyl)-methyl]-phenoxy}-cyclopentanecarbonyl)-amino]-pentanedioic acid 5-tert-butyl ester 1-methyl ester

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide; at 20 ℃; for 24h;
DOI:10.1021/jm010358l

Reference yield:

: 5453-85-0
ethyl cyclopentanecarboxylate

: 328236-10-8
2-[(1-{4-[(3,5-dimethyl-phenylcarbamoyl)-methyl]-phenoxy}-cyclopentanecarbonyl)-amino]-pentanedioic acid 5-tert-butyl ester 1-methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 91.4 percent / NBS / CCl₄ / 6 h / Heating

2: 92 percent / K₂CO₃; KI / ethanol / 25 h / Heating

3: 91 percent / aq. KOH / ethanol / 50 h / Heating

4: 70 percent / HOBt*H₂O; EDC; NMM / dimethylformamide / 24 h / 20 °C

With 4-methyl-morpholine; potassium hydroxide; N-Bromosuccinimide; potassium carbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; potassium iodide; In tetrachloromethane; ethanol; N,N-dimethyl-formamide; 2: Williamson etherification;
DOI:10.1021/jm010358l

Reference yield:

: 120-92-3
cyclopentanone

: 328236-10-8
2-[(1-{4-[(3,5-dimethyl-phenylcarbamoyl)-methyl]-phenoxy}-cyclopentanecarbonyl)-amino]-pentanedioic acid 5-tert-butyl ester 1-methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / NaOH / 15 - 20 °C

2: 70 percent / HOBt*H₂O; EDC; NMM / dimethylformamide / 24 h / 20 °C

With 4-methyl-morpholine; sodium hydroxide; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide;
DOI:10.1021/jm010358l