(+)-ethyl (2S)-3-(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}phenyl)-2-methylpropanoate

Base Information

Chemical Name:(+)-ethyl (2S)-3-(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}phenyl)-2-methylpropanoate
CAS No.:1297551-00-8
Molecular Formula:C₂₃H₂₄Cl₂F₃NO₃
Molecular Weight:490.35
Hs Code.:

Synonyms:(+)-ethyl (2S)-3-(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}phenyl)-2-methylpropanoate

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Chemical Property of (+)-ethyl (2S)-3-(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}phenyl)-2-methylpropanoate

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Technology Process of (+)-ethyl (2S)-3-(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}phenyl)-2-methylpropanoate

There total 11 articles about (+)-ethyl (2S)-3-(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}phenyl)-2-methylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.1%

: 1297550-39-0
(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl chloride

: 1297549-32-6
ethyl (+)-(2S)-3-(3-amino-4-chlorophenyl)-2-methylpropanoate

: 1297551-00-8
(+)-ethyl (2S)-3-(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}phenyl)-2-methylpropanoate

Guidance literature:: ethyl (+)-(2S)-3-(3-amino-4-chlorophenyl)-2-methylpropanoate; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at -10 ℃;

(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl chloride; In tetrahydrofuran; at -10 - 0 ℃; for 1h;
DOI:10.1021/acs.jmedchem.0c02154

Reference yield:

: 1297549-32-6
ethyl (+)-(2S)-3-(3-amino-4-chlorophenyl)-2-methylpropanoate

: (3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoic acid chloride

: 1297551-00-8
(+)-ethyl (2S)-3-(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}phenyl)-2-methylpropanoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at -10 - 0 ℃; for 1h;

Reference yield:

: ethyl (3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoate

: 1297551-00-8
(+)-ethyl (2S)-3-(4-chloro-3-{[(2S,3R)-2-(4-chlorophenyl)-4,4,4-trifluoro-3-methylbutanoyl]amino}phenyl)-2-methylpropanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide; water / 1,4-dioxane / 2 h / 50 °C

1.2: pH 1

2.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / -10 - 20 °C

3.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / -10 - 0 °C

With oxalyl dichloride; water; N-ethyl-N,N-diisopropylamine; sodium hydroxide; N,N-dimethyl-formamide; In tetrahydrofuran; 1,4-dioxane; dichloromethane;