N-(p-nitrophenyl)-5-methyl-2-methylthio-3-thiophenecarbohydrazonoyl chloride

Base Information

• Chemical Name: N-(p-nitrophenyl)-5-methyl-2-methylthio-3-thiophenecarbohydrazonoyl chloride
• CAS No.: 165066-13-7
• Molecular Formula: C₁₃H₁₂ClN₃O₂S₂
• Molecular Weight: 341.842
• Mol file: 165066-13-7.mol

Synonyms:N-(p-nitrophenyl)-5-methyl-2-methylthio-3-thiophenecarbohydrazonoyl chloride

Chemical Property of N-(p-nitrophenyl)-5-methyl-2-methylthio-3-thiophenecarbohydrazonoyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(p-nitrophenyl)-5-methyl-2-methylthio-3-thiophenecarbohydrazonoyl chloride

There total 2 articles about N-(p-nitrophenyl)-5-methyl-2-methylthio-3-thiophenecarbohydrazonoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

N-(p-nitrophenyl)-5-methyl-2-methylthio-3-thiophenecarbohydrazide (165066-10-4) → N-(p-nitrophenyl)-5-methyl-2-methylthio-3-thiophenecarbohydrazonoyl chloride (165066-13-7)

Guidance literature:

With phosphorus pentachloride; In tetrachloromethane; for 2h; Heating;

DOI:10.1007/BF00699146

Reference yield:

2-methylthio-5-methyl-3-thiophenecarboxylic acid (101861-41-0) → N-(p-nitrophenyl)-5-methyl-2-methylthio-3-thiophenecarbohydrazonoyl chloride (165066-13-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) SOCl₂

2: 64 percent / PCl₅ / CCl₄ / 2 h / Heating

With thionyl chloride; phosphorus pentachloride; In tetrachloromethane;

DOI:10.1007/BF00699146

Reference yield: 71.0%

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + N-(p-nitrophenyl)-5-methyl-2-methylthio-3-thiophenecarbohydrazonoyl chloride (165066-13-7) → 3-(5-Methyl-2-methylsulfanyl-thiophen-3-yl)-1-(4-nitro-phenyl)-5-phenyl-4,5-dihydro-1H-pyrazole

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 4.5h;

DOI:10.1007/BF00699146

upstream raw materials:

N-(p-nitrophenyl)-5-methyl-2-methylthio-3-thiophenecarbohydrazide

2-methylthio-5-methyl-3-thiophenecarboxylic acid