(R)-4-Benzyl-3-[(Z)-(S)-2,10-bis-(tert-butyl-diphenyl-silanyloxy)-dec-4-enoyl]-oxazolidin-2-one

Base Information

Chemical Name:(R)-4-Benzyl-3-[(Z)-(S)-2,10-bis-(tert-butyl-diphenyl-silanyloxy)-dec-4-enoyl]-oxazolidin-2-one
CAS No.:782451-80-3
Molecular Formula:C₅₂H₆₃NO₅Si₂
Molecular Weight:838.247
Hs Code.:

Synonyms:(R)-4-Benzyl-3-[(Z)-(S)-2,10-bis-(tert-butyl-diphenyl-silanyloxy)-dec-4-enoyl]-oxazolidin-2-one

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Chemical Property of (R)-4-Benzyl-3-[(Z)-(S)-2,10-bis-(tert-butyl-diphenyl-silanyloxy)-dec-4-enoyl]-oxazolidin-2-one

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Technology Process of (R)-4-Benzyl-3-[(Z)-(S)-2,10-bis-(tert-butyl-diphenyl-silanyloxy)-dec-4-enoyl]-oxazolidin-2-one

There total 1 articles about (R)-4-Benzyl-3-[(Z)-(S)-2,10-bis-(tert-butyl-diphenyl-silanyloxy)-dec-4-enoyl]-oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 132047-92-8
tert-butyl(pent-4-en-1-yloxy)diphenylsilane

: 782451-79-0
(R)-4-Benzyl-3-[(Z)-(S)-2-(tert-butyl-diphenyl-silanyloxy)-5-chloro-pent-4-enoyl]-oxazolidin-2-one

: 782451-80-3
(R)-4-Benzyl-3-[(Z)-(S)-2,10-bis-(tert-butyl-diphenyl-silanyloxy)-dec-4-enoyl]-oxazolidin-2-one

Guidance literature:: tert-butyl(pent-4-en-1-yloxy)diphenylsilane; (R)-4-Benzyl-3-[(Z)-(S)-2-(tert-butyl-diphenyl-silanyloxy)-5-chloro-pent-4-enoyl]-oxazolidin-2-one; With 9-borabicyclo[3.3.1]nonane dimer; In tetrahydrofuran; at 23 ℃; for 2h;

With palladium diacetate; potassium phosphate; Buchwald ligand; In tetrahydrofuran; at 65 ℃; for 18h; Further stages.;
DOI:10.1016/j.tetlet.2004.07.130

Reference yield: 41.0%

: 782451-80-3
(R)-4-Benzyl-3-[(Z)-(S)-2,10-bis-(tert-butyl-diphenyl-silanyloxy)-dec-4-enoyl]-oxazolidin-2-one

: 782451-81-4
C₄₃H₅₅IO₂Si₂

Guidance literature:: (R)-4-Benzyl-3-[(Z)-(S)-2,10-bis-(tert-butyl-diphenyl-silanyloxy)-dec-4-enoyl]-oxazolidin-2-one; With lithium borohydride; In diethyl ether; at 0 ℃; for 8h;

With oxalyl dichloride; dimethyl sulfoxide; triethylamine; In dichloromethane; at -78 - 0 ℃; for 6h;

With chromium dichloride; iodoform; In tetrahydrofuran; at 23 ℃; for 6h; Further stages.;
DOI:10.1016/j.tetlet.2004.07.130

Reference yield:

: 782451-80-3
(R)-4-Benzyl-3-[(Z)-(S)-2,10-bis-(tert-butyl-diphenyl-silanyloxy)-dec-4-enoyl]-oxazolidin-2-one

: 782451-82-5
(5Z,8Z,10E,14Z)-(S)-12,20-Bis-(tert-butyl-diphenyl-silanyloxy)-icosa-5,8,10,14-tetraenoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: LiBH₄ / diethyl ether / 8 h / 0 °C

1.2: (COCl)2; Et₃N; DMSO / CH₂Cl₂ / 6 h / -78 - 0 °C

1.3: 41 percent / CHI₃; CrCl₂ / tetrahydrofuran / 6 h / 23 °C

2.1: CuI; Pd(Ph₃P)4; n-BuNH₂ / benzene / 5 h / 23 °C

2.2: 61 percent / H₂ / P-2 Ni / ethanol / 1.5 h / 760.05 Torr

With copper(l) iodide; lithium borohydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; N-butylamine; In diethyl ether; benzene; 1.2: Swern oxidation / 1.3: Takai iodooxidation / 2.1: Sonogashira alkylation;
DOI:10.1016/j.tetlet.2004.07.130