(3S,4R,6R)-6-[(S)-1-((1aR,3aR,3bS,5aS,6R,8aS,8bS,10R,10aR)-10-Methoxy-3a,5a-dimethyl-hexadecahydro-cyclopenta[a]cyclopropa[2,3]cyclopenta[1,2-f]naphthalen-6-yl)-ethyl]-4-methyl-3-phenylsulfanyl-tetrahydro-pyran-2-one

Base Information

• Chemical Name: (3S,4R,6R)-6-[(S)-1-((1aR,3aR,3bS,5aS,6R,8aS,8bS,10R,10aR)-10-Methoxy-3a,5a-dimethyl-hexadecahydro-cyclopenta[a]cyclopropa[2,3]cyclopenta[1,2-f]naphthalen-6-yl)-ethyl]-4-methyl-3-phenylsulfanyl-tetrahydro-pyran-2-one
• CAS No.: 81426-73-5
• Molecular Formula: C₃₄H₄₈O₃S
• Molecular Weight: 536.819
• Mol file: 81426-73-5.mol

Synonyms:(3S,4R,6R)-6-[(S)-1-((1aR,3aR,3bS,5aS,6R,8aS,8bS,10R,10aR)-10-Methoxy-3a,5a-dimethyl-hexadecahydro-cyclopenta[a]cyclopropa[2,3]cyclopenta[1,2-f]naphthalen-6-yl)-ethyl]-4-methyl-3-phenylsulfanyl-tetrahydro-pyran-2-one

Chemical Property of (3S,4R,6R)-6-[(S)-1-((1aR,3aR,3bS,5aS,6R,8aS,8bS,10R,10aR)-10-Methoxy-3a,5a-dimethyl-hexadecahydro-cyclopenta[a]cyclopropa[2,3]cyclopenta[1,2-f]naphthalen-6-yl)-ethyl]-4-methyl-3-phenylsulfanyl-tetrahydro-pyran-2-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3S,4R,6R)-6-[(S)-1-((1aR,3aR,3bS,5aS,6R,8aS,8bS,10R,10aR)-10-Methoxy-3a,5a-dimethyl-hexadecahydro-cyclopenta[a]cyclopropa[2,3]cyclopenta[1,2-f]naphthalen-6-yl)-ethyl]-4-methyl-3-phenylsulfanyl-tetrahydro-pyran-2-one

There total 3 articles about (3S,4R,6R)-6-[(S)-1-((1aR,3aR,3bS,5aS,6R,8aS,8bS,10R,10aR)-10-Methoxy-3a,5a-dimethyl-hexadecahydro-cyclopenta[a]cyclopropa[2,3]cyclopenta[1,2-f]naphthalen-6-yl)-ethyl]-4-methyl-3-phenylsulfanyl-tetrahydro-pyran-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-6-[(S)-1-((1aR,3aR,3bS,5aS,6R,8aS,8bS,10R,10aR)-10-Methoxy-3a,5a-dimethyl-hexadecahydro-cyclopenta[a]cyclopropa[2,3]cyclopenta[1,2-f]naphthalen-6-yl)-ethyl]-4-methyl-5,6-dihydro-pyran-2-one (81426-70-2) → (3S,4R,6R)-6-[(S)-1-((1aR,3aR,3bS,5aS,6R,8aS,8bS,10R,10aR)-10-Methoxy-3a,5a-dimethyl-hexadecahydro-cyclopenta[a]cyclopropa[2,3]cyclopenta[1,2-f]naphthalen-6-yl)-ethyl]-4-methyl-3-phenylsulfanyl-tetrahydro-pyran-2-one (81426-73-5)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / H₂, NaHCO₃ / 10percent Pd-C / dioxane / 760 Torr / Ambient temperature

2: 15 percent / lithium isopropylcyclohexylamide (LICHA) / tetrahydrofuran; hexamethylphosphoric acid triamide / 0.83 h / -78 °C

3: lithium isopropylcyclohexylamide (LICHA) / 1 h / 0 °C

With hydrogen; sodium hydrogencarbonate; lithium cyclohexylisopropylamide; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; N,N,N,N,N,N-hexamethylphosphoric triamide;

DOI:10.1246/cl.1982.491

Reference yield:

(3R,4R,6R)-6-[(S)-1-((1aR,3aR,3bS,5aS,6R,8aS,8bS,10R,10aR)-10-Methoxy-3a,5a-dimethyl-hexadecahydro-cyclopenta[a]cyclopropa[2,3]cyclopenta[1,2-f]naphthalen-6-yl)-ethyl]-4-methyl-3-phenylsulfanyl-tetrahydro-pyran-2-one (81426-72-4) → (3S,4R,6R)-6-[(S)-1-((1aR,3aR,3bS,5aS,6R,8aS,8bS,10R,10aR)-10-Methoxy-3a,5a-dimethyl-hexadecahydro-cyclopenta[a]cyclopropa[2,3]cyclopenta[1,2-f]naphthalen-6-yl)-ethyl]-4-methyl-3-phenylsulfanyl-tetrahydro-pyran-2-one (81426-73-5)

Guidance literature:

With lithium cyclohexylisopropylamide; at 0 ℃; for 1h;

DOI:10.1246/cl.1982.491

Reference yield:

(4R,6R)-6-[(S)-1-((1aR,3aR,3bS,5aS,6R,8aS,8bS,10R,10aR)-10-Methoxy-3a,5a-dimethyl-hexadecahydro-cyclopenta[a]cyclopropa[2,3]cyclopenta[1,2-f]naphthalen-6-yl)-ethyl]-4-methyl-tetrahydro-pyran-2-one (81426-71-3) → (3S,4R,6R)-6-[(S)-1-((1aR,3aR,3bS,5aS,6R,8aS,8bS,10R,10aR)-10-Methoxy-3a,5a-dimethyl-hexadecahydro-cyclopenta[a]cyclopropa[2,3]cyclopenta[1,2-f]naphthalen-6-yl)-ethyl]-4-methyl-3-phenylsulfanyl-tetrahydro-pyran-2-one (81426-73-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 15 percent / lithium isopropylcyclohexylamide (LICHA) / tetrahydrofuran; hexamethylphosphoric acid triamide / 0.83 h / -78 °C

2: lithium isopropylcyclohexylamide (LICHA) / 1 h / 0 °C

With lithium cyclohexylisopropylamide; In tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide;

DOI:10.1246/cl.1982.491

upstream raw materials:

(3R,4R,6R)-6-[(S)-1-((1aR,3aR,3bS,5aS,6R,8aS,8bS,10R,10aR)-10-Methoxy-3a,5a-dimethyl-hexadecahydro-cyclopenta[a]cyclopropa[2,3]cyclopenta[1,2-f]naphthalen-6-yl)-ethyl]-4-methyl-3-phenylsulfanyl-tetrahydro-pyran-2-one

(R)-6-[(S)-1-((1aR,3aR,3bS,5aS,6R,8aS,8bS,10R,10aR)-10-Methoxy-3a,5a-dimethyl-hexadecahydro-cyclopenta[a]cyclopropa[2,3]cyclopenta[1,2-f]naphthalen-6-yl)-ethyl]-4-methyl-5,6-dihydro-pyran-2-one

(4R,6R)-6-[(S)-1-((1aR,3aR,3bS,5aS,6R,8aS,8bS,10R,10aR)-10-Methoxy-3a,5a-dimethyl-hexadecahydro-cyclopenta[a]cyclopropa[2,3]cyclopenta[1,2-f]naphthalen-6-yl)-ethyl]-4-methyl-tetrahydro-pyran-2-one

Downstream raw materials:

(3R,4R,6R)-3-Hydroxymethyl-6-[(S)-1-((1aR,3aR,3bS,5aS,6R,8aS,8bS,10R,10aR)-10-methoxy-3a,5a-dimethyl-hexadecahydro-cyclopenta[a]cyclopropa[2,3]cyclopenta[1,2-f]naphthalen-6-yl)-ethyl]-4-methyl-3-phenylsulfanyl-tetrahydro-pyran-2-one

(3S,4R,6R)-6-[(S)-1-((1aR,3aR,3bS,5aS,6R,8aS,8bS,10R,10aR)-10-Methoxy-3a,5a-dimethyl-hexadecahydro-cyclopenta[a]cyclopropa[2,3]cyclopenta[1,2-f]naphthalen-6-yl)-ethyl]-3,4-dimethyl-3-phenylsulfanyl-tetrahydro-pyran-2-one