tert-butyl 3-(2-(4-(4-methylpiperazin-1-yl)phenylamino)thieno[3,2-d]pyrimidin-4-ylthio)phenylcarbamate

Base Information

Chemical Name:tert-butyl 3-(2-(4-(4-methylpiperazin-1-yl)phenylamino)thieno[3,2-d]pyrimidin-4-ylthio)phenylcarbamate
CAS No.:1353553-14-6
Molecular Formula:C₂₈H₃₂N₆O₂S₂
Molecular Weight:548.733
Hs Code.:

Synonyms:tert-butyl 3-(2-(4-(4-methylpiperazin-1-yl)phenylamino)thieno[3,2-d]pyrimidin-4-ylthio)phenylcarbamate

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Chemical Property of tert-butyl 3-(2-(4-(4-methylpiperazin-1-yl)phenylamino)thieno[3,2-d]pyrimidin-4-ylthio)phenylcarbamate

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Technology Process of tert-butyl 3-(2-(4-(4-methylpiperazin-1-yl)phenylamino)thieno[3,2-d]pyrimidin-4-ylthio)phenylcarbamate

There total 4 articles about tert-butyl 3-(2-(4-(4-methylpiperazin-1-yl)phenylamino)thieno[3,2-d]pyrimidin-4-ylthio)phenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 16153-81-4
4-(4-Methyl-piperazino)-anilin

: 1353553-13-5
tert-butyl 3-(2-chlorothieno[3,2-d]pyrimidin-4-ylthio)phenylcarbamate

: 1353553-14-6
tert-butyl 3-(2-(4-(4-methylpiperazin-1-yl)phenylamino)thieno[3,2-d]pyrimidin-4-ylthio)phenylcarbamate

Guidance literature:: 4-(4-Methyl-piperazino)-anilin; tert-butyl 3-(2-chlorothieno[3,2-d]pyrimidin-4-ylthio)phenylcarbamate; With trifluoroacetic acid; In iso-butanol; at 100 ℃; for 10h;

With sodium hydrogencarbonate; In water; iso-butanol;

Reference yield:

: 16233-51-5
1H-thieno[3,2-d]pyrimidine-2,4-dione

: 1353553-14-6
tert-butyl 3-(2-(4-(4-methylpiperazin-1-yl)phenylamino)thieno[3,2-d]pyrimidin-4-ylthio)phenylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: trichlorophosphate / 3 h / 200 °C

2: caesium carbonate / N,N'-dimethylsulfonamide / 1 h / 20 °C

3: trifluoroacetic acid / iso-butanol / 10 h / 100 °C

With caesium carbonate; trifluoroacetic acid; trichlorophosphate; In N,N'-dimethylsulfonamide; iso-butanol;

Reference yield:

: 16234-14-3
2,4-dichlorothieno[3,2-d]pyrimidine

: 1353553-14-6
tert-butyl 3-(2-(4-(4-methylpiperazin-1-yl)phenylamino)thieno[3,2-d]pyrimidin-4-ylthio)phenylcarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / N,N'-dimethylsulfonamide / 1 h / 20 °C

2: trifluoroacetic acid / iso-butanol / 10 h / 100 °C

With caesium carbonate; trifluoroacetic acid; In N,N'-dimethylsulfonamide; iso-butanol;