(R)-2-{4-chloro-N-[(1-cyanocyclopropyl)methyl]-phenylsulfonamido}-5,5,5-trifluoropentanamide

Base Information

Chemical Name:(R)-2-{4-chloro-N-[(1-cyanocyclopropyl)methyl]-phenylsulfonamido}-5,5,5-trifluoropentanamide
CAS No.:1370705-47-7
Molecular Formula:C₁₆H₁₇ClF₃N₃O₃S
Molecular Weight:423.843
Hs Code.:

Synonyms:(R)-2-{4-chloro-N-[(1-cyanocyclopropyl)methyl]-phenylsulfonamido}-5,5,5-trifluoropentanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-2-{4-chloro-N-[(1-cyanocyclopropyl)methyl]-phenylsulfonamido}-5,5,5-trifluoropentanamide

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Technology Process of (R)-2-{4-chloro-N-[(1-cyanocyclopropyl)methyl]-phenylsulfonamido}-5,5,5-trifluoropentanamide

There total 1 articles about (R)-2-{4-chloro-N-[(1-cyanocyclopropyl)methyl]-phenylsulfonamido}-5,5,5-trifluoropentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1146699-67-3
(R)-2-(4-chlorophenylsulfonamido)-5,5,5-trifluoropentanamide

: 98730-77-9
1-hydroxymethyl-cyclopropanecarbonitrile

: 1370705-47-7
(R)-2-{4-chloro-N-[(1-cyanocyclopropyl)methyl]-phenylsulfonamido}-5,5,5-trifluoropentanamide

Guidance literature:: With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 23 ℃;
DOI:10.1021/jm300094u

Reference yield:

: 1370705-47-7
(R)-2-{4-chloro-N-[(1-cyanocyclopropyl)methyl]-phenylsulfonamido}-5,5,5-trifluoropentanamide

: C₁₆H₂₀ClF₃N₄O₄S

Guidance literature:: With hydroxylamine; In ethanol; water; at 80 ℃;
DOI:10.1021/jm300094u

Reference yield:

: 1370705-47-7
(R)-2-{4-chloro-N-[(1-cyanocyclopropyl)methyl]-phenylsulfonamido}-5,5,5-trifluoropentanamide

: 1370705-50-2
(R)-2-{N-{[1-(1,2,4-oxadiazol-3-yl)cyclopropyl]methyl}-4-chlorophenylsulfonamido}-5,5,5-trifluoropentanamide

Guidance literature:: Multi-step reaction with 2 steps

1: hydroxylamine / ethanol; water / 80 °C

2: boron trifluoride diethyl etherate / 1,2-dichloro-ethane / 80 °C

With boron trifluoride diethyl etherate; hydroxylamine; In ethanol; water; 1,2-dichloro-ethane;
DOI:10.1021/jm300094u