2-fluoro-6-p-tolylpyridine

Base Information

• Chemical Name: 2-fluoro-6-p-tolylpyridine
• CAS No.: 1245646-59-6
• Molecular Formula: C₁₂H₁₀FN
• Molecular Weight: 187.217
• Mol file: 1245646-59-6.mol

Synonyms:2-fluoro-6-(p-tolyl)pyridine

Chemical Property of 2-fluoro-6-p-tolylpyridine

Chemical Property:

• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

2-fluoro-6-(p-tolyl)pyridine 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-fluoro-6-p-tolylpyridine

There total 6 articles about 2-fluoro-6-p-tolylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

2-bromo-6-fluoropyridine (144100-07-2) + potassium (4-methylphenyl)trifluoroborate → 2-fluoro-6-(p-tolyl)pyridine (1245646-59-6)

Guidance literature:

With 5%-palladium/activated carbon; oxygen; potassium carbonate; In ethanol; water; at 80 ℃; for 1h;

DOI:10.1016/j.cclet.2015.12.022

Reference yield: 93.0%

para-bromotoluene (106-38-7) + potassium 6-fluoropyridine-2-trifluoroborate → 2-fluoro-6-(p-tolyl)pyridine (1245646-59-6)

Guidance literature:

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; sodium carbonate; In ethanol; at 85 ℃; for 16h; Inert atmosphere;

DOI:10.1016/j.tet.2011.12.036

Reference yield: 83.0%

para-bromotoluene (106-38-7) + 2-(6-fluoropyridin-2-yl)-2,3-dihydrobenzo[d][1,3,2]diazaborinin-4(1H)-one → 2-fluoro-6-(p-tolyl)pyridine (1245646-59-6)

Guidance literature:

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; potassium phosphate; palladium diacetate; In 1,4-dioxane; water; at 140 ℃; for 0.5h; Microwave irradiation; Sealed tube;

DOI:10.1039/c8cc05645e

upstream raw materials:

para-bromotoluene

2-bromo-6-fluoropyridine

2,3-dihydro-2-(4-methylphenyl)benzo[d][1,3,2]diazaborinin-4(1H)-one