N-[3-(5-Methoxy-1,2-dimethyl-4,7-dioxo-4,7-dihydro-1H-indol-3-ylmethoxy)-phenyl]-acetamide

Base Information

Chemical Name:N-[3-(5-Methoxy-1,2-dimethyl-4,7-dioxo-4,7-dihydro-1H-indol-3-ylmethoxy)-phenyl]-acetamide
CAS No.:210578-29-3
Molecular Formula:C₂₀H₂₀N₂O₅
Molecular Weight:368.389
Hs Code.:

Synonyms:N-[3-(5-Methoxy-1,2-dimethyl-4,7-dioxo-4,7-dihydro-1H-indol-3-ylmethoxy)-phenyl]-acetamide

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Chemical Property of N-[3-(5-Methoxy-1,2-dimethyl-4,7-dioxo-4,7-dihydro-1H-indol-3-ylmethoxy)-phenyl]-acetamide

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Technology Process of N-[3-(5-Methoxy-1,2-dimethyl-4,7-dioxo-4,7-dihydro-1H-indol-3-ylmethoxy)-phenyl]-acetamide

There total 5 articles about N-[3-(5-Methoxy-1,2-dimethyl-4,7-dioxo-4,7-dihydro-1H-indol-3-ylmethoxy)-phenyl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 161518-24-7
3-(hydroxymethyl)-5-methoxy-1,2-dimethyl-1H-indole-4,7-dione

: 210578-29-3
N-[3-(5-Methoxy-1,2-dimethyl-4,7-dioxo-4,7-dihydro-1H-indol-3-ylmethoxy)-phenyl]-acetamide

Guidance literature:: Multi-step reaction with 2 steps

1: SOCl₂ / 0.5 h / Ambient temperature

2: K₂CO₃ / dimethylformamide / Ambient temperature

With thionyl chloride; potassium carbonate; In N,N-dimethyl-formamide;
DOI:10.1021/jm970744w

Reference yield:

: 205177-88-4
5-Methoxy-1,2-dimethyl-4,7-dioxo-4,7-dihydro-1H-indole-3-carboxylic acid ethyl ester

: 210578-29-3
N-[3-(5-Methoxy-1,2-dimethyl-4,7-dioxo-4,7-dihydro-1H-indol-3-ylmethoxy)-phenyl]-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1: aq. sodium dithionite / CHCl₃; ethanol

2: DIBAL-H / CH₂Cl₂ / 2 h / -30 °C

3: SOCl₂ / 0.5 h / Ambient temperature

4: K₂CO₃ / dimethylformamide / Ambient temperature

With thionyl chloride; sodium dithionite; diisobutylaluminium hydride; potassium carbonate; In ethanol; dichloromethane; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/jm970744w

Reference yield:

: ethyl 4,7-dihydroxy-5-methoxy-1,2-dimethylindole-3-carboxylate

: 210578-29-3
N-[3-(5-Methoxy-1,2-dimethyl-4,7-dioxo-4,7-dihydro-1H-indol-3-ylmethoxy)-phenyl]-acetamide

Guidance literature:: Multi-step reaction with 3 steps

1: DIBAL-H / CH₂Cl₂ / 2 h / -30 °C

2: SOCl₂ / 0.5 h / Ambient temperature

3: K₂CO₃ / dimethylformamide / Ambient temperature

With thionyl chloride; diisobutylaluminium hydride; potassium carbonate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm970744w