<<3,4-cis-bis<(methoxyethoxy)methoxy>pyrrolidino>carbonyl>-O-methyltyrosine methyl ester

Base Information

• Chemical Name: <<3,4-cis-bis<(methoxyethoxy)methoxy>pyrrolidino>carbonyl>-O-methyltyrosine methyl ester
• CAS No.: 127944-61-0
• Molecular Formula: C₂₄H₃₈N₂O₁₀
• Molecular Weight: 514.573

Synonyms:<<3,4-cis-bis<(methoxyethoxy)methoxy>pyrrolidino>carbonyl>-O-methyltyrosine methyl ester

Chemical Property of <<3,4-cis-bis<(methoxyethoxy)methoxy>pyrrolidino>carbonyl>-O-methyltyrosine methyl ester

Chemical Property:

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Technology Process of <<3,4-cis-bis<(methoxyethoxy)methoxy>pyrrolidino>carbonyl>-O-methyltyrosine methyl ester

There total 2 articles about <<3,4-cis-bis<(methoxyethoxy)methoxy>pyrrolidino>carbonyl>-O-methyltyrosine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

3,4-cis-bis<(methoxyethoxy)methoxy>pyrrolidine (127944-58-5) + α-isocyanato-L-O-methyltyrosine methyl ester (52177-38-5) → <<3,4-cis-bis<(methoxyethoxy)methoxy>pyrrolidino>carbonyl>-O-methyltyrosine methyl ester (127944-61-0)

Guidance literature:

In dichloromethane; 1.) 0 deg C, 30 min, 2.) RT, overnight;

DOI:10.1021/jm00169a024

Reference yield:

1-<(benzyloxy)carbonyl>-3,4-cis-bis<(methoxyethoxy)methoxy>pyrrolidine (127944-46-1) → <<3,4-cis-bis<(methoxyethoxy)methoxy>pyrrolidino>carbonyl>-O-methyltyrosine methyl ester (127944-61-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / H₂ / 10percent Pd/C / methanol / 12 h

2: 84 percent / CH₂Cl₂ / 1.) 0 deg C, 30 min, 2.) RT, overnight

With hydrogen; palladium on activated charcoal; In methanol; dichloromethane;

DOI:10.1021/jm00169a024

Reference yield: 100.0%

<<3,4-cis-bis<(methoxyethoxy)methoxy>pyrrolidino>carbonyl>-O-methyltyrosine methyl ester (127944-61-0) → <<3,4-cis-bis<(methoxyethoxy)methoxy>pyrrolidino>carbonyl>-O-methyltyrosine (119589-10-5)

Guidance literature:

With lithium hydroxide; In 1,4-dioxane; at 0 ℃; for 1h;

DOI:10.1021/jm00169a024

upstream raw materials:

3,4-cis-bis<(methoxyethoxy)methoxy>pyrrolidine

α-isocyanato-L-O-methyltyrosine methyl ester

1-<(benzyloxy)carbonyl>-3,4-cis-bis<(methoxyethoxy)methoxy>pyrrolidine

Downstream raw materials:

<<3,4-cis-bis<(methoxyethoxy)methoxy>pyrrolidino>carbonyl>-O-methyltyrosine

(3R,4S)-3,4-Bis-(2-methoxy-ethoxymethoxy)-pyrrolidine-1-carboxylic acid [(S)-1-[(S)-1-[(1S,2R)-1-cyclohexylmethyl-2-((S)-3-ethyl-2-oxo-oxazolidin-5-yl)-2-hydroxy-ethylcarbamoyl]-2-(3H-imidazol-4-yl)-ethylcarbamoyl]-2-(4-methoxy-phenyl)-ethyl]-amide

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