1-(R)-<methyl>-2,8-diketo-10-(R)-(1-methylethenyl)-9-(4-methoxybenzyl)-3,9-diazatricyclo<5.2.2.0^3,7>undecane

Base Information

• Chemical Name: 1-(R)-<methyl>-2,8-diketo-10-(R)-(1-methylethenyl)-9-(4-methoxybenzyl)-3,9-diazatricyclo<5.2.2.0^3,7>undecane
• CAS No.: 116051-31-1
• Molecular Formula: C₃₄H₃₉N₃O₅
• Molecular Weight: 569.701

Synonyms:1-(R)-<methyl>-2,8-diketo-10-(R)-(1-methylethenyl)-9-(4-methoxybenzyl)-3,9-diazatricyclo<5.2.2.0^3,7>undecane

Chemical Property of 1-(R)-<methyl>-2,8-diketo-10-(R)-(1-methylethenyl)-9-(4-methoxybenzyl)-3,9-diazatricyclo<5.2.2.0^3,7>undecane

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

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Technology Process of 1-(R)-<methyl>-2,8-diketo-10-(R)-(1-methylethenyl)-9-(4-methoxybenzyl)-3,9-diazatricyclo<5.2.2.0^3,7>undecane

There total 16 articles about 1-(R)-<methyl>-2,8-diketo-10-(R)-(1-methylethenyl)-9-(4-methoxybenzyl)-3,9-diazatricyclo<5.2.2.0^3,7>undecane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 13.0%

3-[(R)-8a-((E)-4-Chloro-3-methyl-but-2-enyl)-2-(4-methoxy-benzyl)-1,4-dioxo-octahydro-pyrrolo[1,2-a]pyrazin-3-ylmethyl]-indole-1-carboxylic acid tert-butyl ester (116025-41-3) → C29H31N3O3 (124268-84-4) + 1-(R)-<methyl>-2,8-diketo-10-(R)-(1-methylethenyl)-9-(4-methoxybenzyl)-3,9-diazatricyclo<5.2.2.03,7>undecane (116051-31-1) + 1-(R)-<methyl>-2,8-diketo-10-(S)-(1-methylethenyl)-9-(4-methoxybenzyl)-3,9-diazatricyclo<5.2.2.03,7>undecane (116005-49-3)

Guidance literature:

With sodium hydride; In benzene; for 30h; Yields of byproduct given; Heating;

Reference yield:

3-[(R)-8a-((E)-4-Chloro-3-methyl-but-2-enyl)-2-(4-methoxy-benzyl)-1,4-dioxo-octahydro-pyrrolo[1,2-a]pyrazin-3-ylmethyl]-indole-1-carboxylic acid tert-butyl ester (116025-41-3) → 1-(R)-<methyl>-2,8-diketo-10-(R)-(1-methylethenyl)-9-(4-methoxybenzyl)-3,9-diazatricyclo<5.2.2.03,7>undecane (116051-31-1) + 1-(R)-<methyl>-2,8-diketo-10-(S)-(1-methylethenyl)-9-(4-methoxybenzyl)-3,9-diazatricyclo<5.2.2.03,7>undecane (116005-49-3)

Guidance literature:

With 18-crown-6 ether; sodium hydride; In tetrahydrofuran; for 5h; Yield given. Yields of byproduct given. Title compound not separated from byproducts; Heating;

Reference yield:

3-(Dimethylaminomethyl)indole (87-52-5) → 1-(R)-<methyl>-2,8-diketo-10-(R)-(1-methylethenyl)-9-(4-methoxybenzyl)-3,9-diazatricyclo<5.2.2.03,7>undecane (116051-31-1)

Guidance literature:

Multi-step reaction with 5 steps

1: 62 percent / tri-n-butylphosphine / acetonitrile / 7 h / Heating

2: 78 percent / lithium chloride, H₂O / hexamethylphosphoric acid triamide / 2 h / 100 - 105 °C

4: collidine, LiCl, methanesulfonyl chloride / dimethylformamide / 25 °C

5: NaH / benzene / 30 h / Heating

With 2,3,5-trimethyl-pyridine; tributylphosphine; water; sodium hydride; methanesulfonyl chloride; lithium chloride; In N,N,N,N,N,N-hexamethylphosphoric triamide; N,N-dimethyl-formamide; acetonitrile; benzene;

upstream raw materials:

3-[(R)-8a-((E)-4-Chloro-3-methyl-but-2-enyl)-2-(4-methoxy-benzyl)-1,4-dioxo-octahydro-pyrrolo[1,2-a]pyrazin-3-ylmethyl]-indole-1-carboxylic acid tert-butyl ester

3-(Dimethylaminomethyl)indole

(2R,5R)-5-allyl-2-tert-butyl-1-aza-3-oxabicyclo<3.3.0>octan-4-one

(-)-2-(R)-allyl-2-<(4-methoxybenzyl)carboxamido>pyrrolidine

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