t-butyl (3R,4R)-2-(4-methylthio-2-oxo-3-triphenylmethylaminoazetidin-1-yl)acetate

Base Information

Chemical Name:t-butyl (3R,4R)-2-(4-methylthio-2-oxo-3-triphenylmethylaminoazetidin-1-yl)acetate
CAS No.:72819-38-6
Molecular Formula:C₂₉H₃₂N₂O₃S
Molecular Weight:488.651
Hs Code.:

Synonyms:t-butyl (3R,4R)-2-(4-methylthio-2-oxo-3-triphenylmethylaminoazetidin-1-yl)acetate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of t-butyl (3R,4R)-2-(4-methylthio-2-oxo-3-triphenylmethylaminoazetidin-1-yl)acetate

Chemical Property:

Purity/Quality:

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Technology Process of t-butyl (3R,4R)-2-(4-methylthio-2-oxo-3-triphenylmethylaminoazetidin-1-yl)acetate

There total 1 articles about t-butyl (3R,4R)-2-(4-methylthio-2-oxo-3-triphenylmethylaminoazetidin-1-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5292-43-3
bromoacetic acid tert-butyl ester

: 59461-72-2
(3R,4R)-4-methylthio-3-triphenylmethylaminoazetidin-2-one

: 72819-38-6
t-butyl (3R,4R)-2-(4-methylthio-2-oxo-3-triphenylmethylaminoazetidin-1-yl)acetate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; for 20h; Ambient temperature;
DOI:10.1039/P19810002544

Reference yield:

: 72819-38-6
t-butyl (3R,4R)-2-(4-methylthio-2-oxo-3-triphenylmethylaminoazetidin-1-yl)acetate

: [(R)-2-Chloro-4-oxo-3-(trityl-amino)-azetidin-1-yl]-acetic acid tert-butyl ester

Guidance literature:: With chlorine; In tetrachloromethane; at -20 - 0 ℃; for 1.5h;
DOI:10.1039/P19810002544

Reference yield:

: 72819-38-6
t-butyl (3R,4R)-2-(4-methylthio-2-oxo-3-triphenylmethylaminoazetidin-1-yl)acetate

: 72819-43-3
t-butyl (8S,8aR)-7,8-dihydro-7-oxo-3-phenyl-8-triphenylmethylamino-8aH-azeto<1.2-a>-v-triazolo<3,4-c>pyrimidine-5-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: chlorine / CCl₄ / 1.5 h / -20 - 0 °C

2: 6.11 g / sodium azide / dimethylformamide / 18 h / Ambient temperature

3: 3.59 g / lithium hexamethyldisilazane / tetrahydrofuran; hexane / -76 °C

4: 1.48 g / toluene / Heating

5: toluene / 16 h / Heating

6: 932 mg / m-chloroperbenzoic acid / ethyl acetate / 0 °C

With sodium azide; chlorine; 3-chloro-benzenecarboperoxoic acid; lithium hexamethyldisilazane; In tetrahydrofuran; tetrachloromethane; hexane; ethyl acetate; N,N-dimethyl-formamide; toluene;
DOI:10.1039/P19810002544