5-(1-((2-isobutoxypyridin-4-yl)methyl)-5-methyl-1H-1,2,4-triazol-3-yl)-3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole

Base Information

Chemical Name:5-(1-((2-isobutoxypyridin-4-yl)methyl)-5-methyl-1H-1,2,4-triazol-3-yl)-3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole
CAS No.:1570496-14-8
Molecular Formula:C₂₂H₂₁F₃N₆O₃
Molecular Weight:474.442
Hs Code.:

Synonyms:5-(1-((2-isobutoxypyridin-4-yl)methyl)-5-methyl-1H-1,2,4-triazol-3-yl)-3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole

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Chemical Property of 5-(1-((2-isobutoxypyridin-4-yl)methyl)-5-methyl-1H-1,2,4-triazol-3-yl)-3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole

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Technology Process of 5-(1-((2-isobutoxypyridin-4-yl)methyl)-5-methyl-1H-1,2,4-triazol-3-yl)-3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole

There total 9 articles about 5-(1-((2-isobutoxypyridin-4-yl)methyl)-5-methyl-1H-1,2,4-triazol-3-yl)-3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 78-77-3
Isobutyl bromide

: 1570496-11-5
4-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-1,2,4-triazol-1-yl)methyl)pyridin-2(1H)-one

: 1570496-12-6
4-[(5-methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-1,2,4-triazol-1-yl)methyl]-1-(2-methylpropyl)-1,2-dihydropyridin-2-one

: 1570496-14-8
5-(1-((2-isobutoxypyridin-4-yl)methyl)-5-methyl-1H-1,2,4-triazol-3-yl)-3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 55 ℃; for 16h;

Reference yield:

: C₁₂H₁₀F₃N₅O₃

: 1570496-12-6
4-[(5-methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-1,2,4-triazol-1-yl)methyl]-1-(2-methylpropyl)-1,2-dihydropyridin-2-one

: 1570496-14-8
5-(1-((2-isobutoxypyridin-4-yl)methyl)-5-methyl-1H-1,2,4-triazol-3-yl)-3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole

Guidance literature:: Multi-step reaction with 3 steps

1: ethylene glycol / 3 h / 180 °C

2: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C

3: potassium carbonate / N,N-dimethyl-formamide / 16 h / 55 °C

With potassium carbonate; In ethylene glycol; N,N-dimethyl-formamide;

Reference yield:

: 4-(trifluoromethoxy)benzamidoxime

: 1570496-12-6
4-[(5-methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-1,2,4-triazol-1-yl)methyl]-1-(2-methylpropyl)-1,2-dihydropyridin-2-one

: 1570496-14-8
5-(1-((2-isobutoxypyridin-4-yl)methyl)-5-methyl-1H-1,2,4-triazol-3-yl)-3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazole

Guidance literature:: Multi-step reaction with 6 steps

1: pyridine / chloroform / 3 h / 0 °C / Reflux

2: hydrazine hydrate / ethanol

3: sodium hydroxide / tetrahydrofuran / Reflux

4: ethylene glycol / 3 h / 180 °C

5: potassium carbonate / N,N-dimethyl-formamide / 16 h / 20 °C

6: potassium carbonate / N,N-dimethyl-formamide / 16 h / 55 °C

With pyridine; potassium carbonate; hydrazine hydrate; sodium hydroxide; In tetrahydrofuran; ethanol; chloroform; ethylene glycol; N,N-dimethyl-formamide;