N₁-[(3-endo)-8-(4-chlorobenzyl)-8-azabicyclo[3.2.1]oct-3-yl]glycinamide

Base Information

Chemical Name:N₁-[(3-endo)-8-(4-chlorobenzyl)-8-azabicyclo[3.2.1]oct-3-yl]glycinamide
CAS No.:917107-26-7
Molecular Formula:C₁₆H₂₂ClN₃O
Molecular Weight:307.823
Hs Code.:

N<sub>1</sub>-[(3-endo)-8-(4-chlorobenzyl)-8-azabicyclo[3.2.1]oct-3-yl]glycinamide

Synonyms:N₁-[(3-endo)-8-(4-chlorobenzyl)-8-azabicyclo[3.2.1]oct-3-yl]glycinamide

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Chemical Property of N₁-[(3-endo)-8-(4-chlorobenzyl)-8-azabicyclo[3.2.1]oct-3-yl]glycinamide

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Technology Process of N₁-[(3-endo)-8-(4-chlorobenzyl)-8-azabicyclo[3.2.1]oct-3-yl]glycinamide

There total 2 articles about N₁-[(3-endo)-8-(4-chlorobenzyl)-8-azabicyclo[3.2.1]oct-3-yl]glycinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 917107-25-6
tert-butyl 2-((3-endo)-8-(4-chlorobenzyl)-8-aza-bicyclo[3.2.1]octan-3-ylamino)-2-oxoethylcarbamate

: 917107-26-7
N₁-[(3-endo)-8-(4-chlorobenzyl)-8-azabicyclo[3.2.1]oct-3-yl]glycinamide

Guidance literature:: tert-butyl 2-((3-endo)-8-(4-chlorobenzyl)-8-aza-bicyclo[3.2.1]octan-3-ylamino)-2-oxoethylcarbamate; With trifluoroacetic acid; at 20 ℃; for 0.5h;

With potassium carbonate; In water; at 0 ℃;

Reference yield:

: 917241-78-2
(3-endo)-8-(4-chlorobenzyl)-8-azabicyclo[3.2.1]octan-3-amine

: 917107-26-7
N₁-[(3-endo)-8-(4-chlorobenzyl)-8-azabicyclo[3.2.1]oct-3-yl]glycinamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.08 h / 20 °C

1.2: 48 h / 20 °C

2.1: trifluoroacetic acid / 0.5 h / 20 °C

2.2: 0 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid; In dichloromethane;

Reference yield: 62.0%

: 917107-26-7
N₁-[(3-endo)-8-(4-chlorobenzyl)-8-azabicyclo[3.2.1]oct-3-yl]glycinamide

: 3-chloro-N-(2-((3-endo)-8-(4-chlorobenzyl)-8-azabicyclo[3.2.1]octan-3-ylamino)-2-oxoethyl)benzamide

Guidance literature:: 3-chlorobenzoate; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 0.166667h;

N₁-[(3-endo)-8-(4-chlorobenzyl)-8-azabicyclo[3.2.1]oct-3-yl]glycinamide; In dichloromethane; at 20 ℃; for 2.5h;