methyl 4-acetamido-2-oxo-α-<2-(phenylmethoxy)ethoxy>-1(2H)-pyrimidineacetate

Base Information

• Chemical Name: methyl 4-acetamido-2-oxo-α-<2-(phenylmethoxy)ethoxy>-1(2H)-pyrimidineacetate
• CAS No.: 121653-76-7
• Molecular Formula: C₁₈H₂₁N₃O₆
• Molecular Weight: 375.381
• Mol file: 121653-76-7.mol

Synonyms:methyl 4-acetamido-2-oxo-α-<2-(phenylmethoxy)ethoxy>-1(2H)-pyrimidineacetate

Chemical Property of methyl 4-acetamido-2-oxo-α-<2-(phenylmethoxy)ethoxy>-1(2H)-pyrimidineacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 4-acetamido-2-oxo-α-<2-(phenylmethoxy)ethoxy>-1(2H)-pyrimidineacetate

There total 3 articles about methyl 4-acetamido-2-oxo-α-<2-(phenylmethoxy)ethoxy>-1(2H)-pyrimidineacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Benzyloxyethanol (622-08-2,1201808-31-2) → methyl 4-acetamido-2-oxo-α-<2-(phenylmethoxy)ethoxy>-1(2H)-pyrimidineacetate (121653-76-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 5.07 g / benzene / 1.5 h / Heating

2: Et₃N / CH₂Cl₂ / 1.25 h / -18 - -15 °C

3: 1.) N,O-bis(trimethylsilyl)acetamide / 2.) SnCl₄ / 1.) CH₂Cl₂, 2.25 h, 2.) a) ice-bath temperature, b) 25 deg C, 17 h

With N,O-bis-(trimethylsilyl)-acetamide; triethylamine; tin(IV) chloride; In dichloromethane; benzene;

DOI:10.1021/jm00128a032

Reference yield:

(2-Benzyloxy-ethoxy)-hydroxy-acetic acid methyl ester (121653-72-3) → methyl 4-acetamido-2-oxo-α-<2-(phenylmethoxy)ethoxy>-1(2H)-pyrimidineacetate (121653-76-7)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂ / 1.25 h / -18 - -15 °C

2: 1.) N,O-bis(trimethylsilyl)acetamide / 2.) SnCl₄ / 1.) CH₂Cl₂, 2.25 h, 2.) a) ice-bath temperature, b) 25 deg C, 17 h

With N,O-bis-(trimethylsilyl)-acetamide; triethylamine; tin(IV) chloride; In dichloromethane;

DOI:10.1021/jm00128a032

Reference yield:

4-N-Acetylcytosine (14631-20-0) + methyl chloro<2-(phenylmethoxy)ethoxy>acetate (121653-73-4) → methyl 4-acetamido-2-oxo-α-<2-(phenylmethoxy)ethoxy>-1(2H)-pyrimidineacetate (121653-76-7)

Guidance literature:

With N,O-bis-(trimethylsilyl)-acetamide; tin(IV) chloride; Yield given. Multistep reaction; 1.) CH₂Cl₂, 2.25 h, 2.) a) ice-bath temperature, b) 25 deg C, 17 h;

DOI:10.1021/jm00128a032

upstream raw materials:

4-N-Acetylcytosine

methyl chloro<2-(phenylmethoxy)ethoxy>acetate

2-Benzyloxyethanol

(2-Benzyloxy-ethoxy)-hydroxy-acetic acid methyl ester

Downstream raw materials:

4-<<(1,1-dimethylethoxy)carbonyl>amino>-2-oxo-N-(phenylmethoxy)-α-<2-(phenylmethoxy)ethoxy>-1(2H)-pyrimidineacetamide

methyl 4-<<(1,1-dimethylethoxy)carbonyl>amino>-2-oxo-α-<2-(phenylmethoxy)ethoxy>-1(2H)-pyrimidineacetate

4-<<(1,1-dimethylethoxy)carbonyl>amino>-2-oxo-α-<2-(phenylmethoxy)ethoxy>-1(2H)-pyrimidineacetic acid

methyl 4-amino-2-oxo-α-<2-(phenylmethoxy)ethoxy>-1(2H)-pyrimidineacetate

Refernces