1-[(E)-(3-Phenyl-acryloyl)]-aziridine-2-carboxylic acid isopropyl ester

Base Information

• Chemical Name: 1-[(E)-(3-Phenyl-acryloyl)]-aziridine-2-carboxylic acid isopropyl ester
• CAS No.: 155878-96-9
• Molecular Formula: C₁₅H₁₇NO₃
• Molecular Weight: 259.305
• Mol file: 155878-96-9.mol

Synonyms:1-[(E)-(3-Phenyl-acryloyl)]-aziridine-2-carboxylic acid isopropyl ester

Chemical Property of 1-[(E)-(3-Phenyl-acryloyl)]-aziridine-2-carboxylic acid isopropyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 1-[(E)-(3-Phenyl-acryloyl)]-aziridine-2-carboxylic acid isopropyl ester

There total 1 articles about 1-[(E)-(3-Phenyl-acryloyl)]-aziridine-2-carboxylic acid isopropyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

cinnamoyl chloride (102-92-1,17082-09-6) + aziridine-2-carboxylic acid isopropyl ester (5950-39-0) → 1-[(E)-(3-Phenyl-acryloyl)]-aziridine-2-carboxylic acid isopropyl ester (155878-96-9)

Guidance literature:

With triethylamine; In benzene; for 3h; Ambient temperature;

DOI:10.1039/a604091h

Reference yield: 25.0%

1-[(E)-(3-Phenyl-acryloyl)]-aziridine-2-carboxylic acid isopropyl ester (155878-96-9) → 2-[(E)-(3-Phenyl-acryloyl)amino]-acrylic acid isopropyl ester + 2-((E)-Styryl)-4,5-dihydro-oxazole-5-carboxylic acid isopropyl ester + 2-((E)-Styryl)-4,5-dihydro-oxazole-4-carboxylic acid isopropyl ester (155878-98-1)

Guidance literature:

With sodium iodide; In acetone; for 20h; Ambient temperature;

DOI:10.1039/a604091h

Reference yield:

1-[(E)-(3-Phenyl-acryloyl)]-aziridine-2-carboxylic acid isopropyl ester (155878-96-9) → 2-((E)-Styryl)-oxazole-4-carboxylic acid isopropyl ester

Guidance literature:

Multi-step reaction with 2 steps

1: 78 percent / CF₃SO₃H / benzene; light petroleum / 0.5 h / Ambient temperature

2: 72 percent / NiO₂ / benzene / 16 h / Heating

With nickel(IV) oxide; trifluorormethanesulfonic acid; In Petroleum ether; benzene;

DOI:10.1039/a604091h

upstream raw materials:

cinnamoyl chloride

aziridine-2-carboxylic acid isopropyl ester

Downstream raw materials:

2-((E)-Styryl)-4,5-dihydro-oxazole-4-carboxylic acid isopropyl ester