(E)-N-[4-(3-chloro-4-fluoroanilino)-7-((7-methyl-7-azaspirocyclic[3.5]nonan-2-yl)methoxy)quinazolin-6-yl]-2-pentenamide

Base Information

Chemical Name:(E)-N-[4-(3-chloro-4-fluoroanilino)-7-((7-methyl-7-azaspirocyclic[3.5]nonan-2-yl)methoxy)quinazolin-6-yl]-2-pentenamide
CAS No.:1363358-85-3
Molecular Formula:C₂₉H₃₃ClFN₅O₂
Molecular Weight:538.065
Hs Code.:

Synonyms:(E)-N-[4-(3-chloro-4-fluoroanilino)-7-((7-methyl-7-azaspirocyclic[3.5]nonan-2-yl)methoxy)quinazolin-6-yl]-2-pentenamide

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Chemical Property of (E)-N-[4-(3-chloro-4-fluoroanilino)-7-((7-methyl-7-azaspirocyclic[3.5]nonan-2-yl)methoxy)quinazolin-6-yl]-2-pentenamide

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Technology Process of (E)-N-[4-(3-chloro-4-fluoroanilino)-7-((7-methyl-7-azaspirocyclic[3.5]nonan-2-yl)methoxy)quinazolin-6-yl]-2-pentenamide

There total 7 articles about (E)-N-[4-(3-chloro-4-fluoroanilino)-7-((7-methyl-7-azaspirocyclic[3.5]nonan-2-yl)methoxy)quinazolin-6-yl]-2-pentenamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 8.0%

: 13991-37-2
trans-2-pentenoic acid

N⁴-(3-chloro-4-fluorophenyl)-7-((7-methyl-7-azaspiro[3.5]non-2-yl)methoxy)quinazolin-4,6-diamine: 1363359-84-5
N⁴-(3-chloro-4-fluorophenyl)-7-((7-methyl-7-azaspiro[3.5]non-2-yl)methoxy)quinazolin-4,6-diamine

: 1363358-85-3
(E)-N-[4-(3-chloro-4-fluoroanilino)-7-((7-methyl-7-azaspirocyclic[3.5]nonan-2-yl)methoxy)quinazolin-6-yl]-2-pentenamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 12h;

Reference yield:

N-(4-(3-chloro-4-fluorophenyl))-7-((7-methyl-7-azaspiro[3.5]nonan-2-yl)methoxy)-6-nitroquinazolin-4-amine: 1363359-83-4
N-(4-(3-chloro-4-fluorophenyl))-7-((7-methyl-7-azaspiro[3.5]nonan-2-yl)methoxy)-6-nitroquinazolin-4-amine

: 1363358-85-3
(E)-N-[4-(3-chloro-4-fluoroanilino)-7-((7-methyl-7-azaspirocyclic[3.5]nonan-2-yl)methoxy)quinazolin-6-yl]-2-pentenamide

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid; iron / ethanol / 12 h / 20 °C

2: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 20 °C

With iron; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; In ethanol; N,N-dimethyl-formamide;

Reference yield:

: 16499-57-3
7-fluoro-3H-quinazolin-4-one

: 1363358-85-3
(E)-N-[4-(3-chloro-4-fluoroanilino)-7-((7-methyl-7-azaspirocyclic[3.5]nonan-2-yl)methoxy)quinazolin-6-yl]-2-pentenamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: nitric acid; sulfuric acid

2.1: thionyl chloride

3.1: isopropyl alcohol

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C / Cooling with ice; Inert atmosphere

4.2: 20 °C

5.1: acetic acid; iron / ethanol / 12 h / 20 °C

6.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 12 h / 20 °C

With thionyl chloride; sulfuric acid; nitric acid; iron; sodium hydride; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; In ethanol; N,N-dimethyl-formamide; isopropyl alcohol; mineral oil;