2,3,4-triisopropyl-benzenesulfonic acid 9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2-phenylacetylamino-9H-purin-6-yl ester

Base Information

• Chemical Name: 2,3,4-triisopropyl-benzenesulfonic acid 9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2-phenylacetylamino-9H-purin-6-yl ester
• CAS No.: 934500-66-0
• Molecular Formula: C₄₅H₆₉N₅O₇SSi₂
• Molecular Weight: 880.309
• Mol file: 934500-66-0.mol

Synonyms:2,3,4-triisopropyl-benzenesulfonic acid 9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2-phenylacetylamino-9H-purin-6-yl ester

Chemical Property of 2,3,4-triisopropyl-benzenesulfonic acid 9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2-phenylacetylamino-9H-purin-6-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,3,4-triisopropyl-benzenesulfonic acid 9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2-phenylacetylamino-9H-purin-6-yl ester

There total 2 articles about 2,3,4-triisopropyl-benzenesulfonic acid 9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2-phenylacetylamino-9H-purin-6-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

tri-isopropylbenzenesulfonyl chloride + N-{9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-oxo-6,9-dihydro-1H-purin-2-yl}-2-phenyl-acetamide (136112-92-0) → 2,3,4-triisopropyl-benzenesulfonic acid 9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2-phenylacetylamino-9H-purin-6-yl ester (934500-66-0)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 20 ℃; for 1h;

DOI:10.1016/j.tetlet.2007.01.064

Reference yield:

2-azidomethyl-benzoic acid 4-{9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2-phenylacetylamino-9H-purin-6-yloxymethyl}-phenyl ester (934500-67-1) → 2,3,4-triisopropyl-benzenesulfonic acid 9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2-phenylacetylamino-9H-purin-6-yl ester (934500-66-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 100 percent / MePPh₂; 2-mercaptoethanol / dioxane; H₂O / 0.17 h / 20 °C

2: 85 percent / Et₃N; DMAP / CH₂Cl₂ / 1 h / 20 °C

With dmap; triethylamine; diphenyl(methyl)phosphine; 2-hydroxyethanethiol; In 1,4-dioxane; dichloromethane; water;

DOI:10.1016/j.tetlet.2007.01.064

Reference yield: 77.0%

4-[(2-azidomethyl)-benzoyloxy]benzyl alcohol + 2,3,4-triisopropyl-benzenesulfonic acid 9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2-phenylacetylamino-9H-purin-6-yl ester (934500-66-0) → 2-azidomethyl-benzoic acid 4-{9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2-phenylacetylamino-9H-purin-6-yloxymethyl}-phenyl ester (934500-67-1)

Guidance literature:

2,3,4-triisopropyl-benzenesulfonic acid 9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2-phenylacetylamino-9H-purin-6-yl ester; With 1-Methylpyrrolidine; In dichloromethane; at 0 ℃; for 0.166667h;

4-[(2-azidomethyl)-benzoyloxy]benzyl alcohol; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dichloromethane; at 0 ℃; for 1.5h;

DOI:10.1016/j.tetlet.2007.01.064

upstream raw materials:

N-{9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-oxo-6,9-dihydro-1H-purin-2-yl}-2-phenyl-acetamide

2-azidomethyl-benzoic acid 4-{9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2-phenylacetylamino-9H-purin-6-yloxymethyl}-phenyl ester

Downstream raw materials:

2-azidomethyl-benzoic acid 4-{9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2-phenylacetylamino-9H-purin-6-yloxymethyl}-phenyl ester

N-{9-[4-(tert-butyl-dimethyl-silanyloxy)-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-6-oxo-6,9-dihydro-1H-purin-2-yl}-2-phenyl-acetamide