tert-Butyl 4-[(5-bromo-3-nitropyridin-2-yl)amino]piperidine-1-carboxylate

Base Information

• Chemical Name: tert-Butyl 4-[(5-bromo-3-nitropyridin-2-yl)amino]piperidine-1-carboxylate
• CAS No.: 1127119-18-9
• Molecular Formula: C₁₅H₂₁BrN₄O₄
• Molecular Weight: 401.26

Synonyms:tert-Butyl 4-[(5-bromo-3-nitropyridin-2-yl)amino]piperidine-1-carboxylate

Chemical Property of tert-Butyl 4-[(5-bromo-3-nitropyridin-2-yl)amino]piperidine-1-carboxylate

Chemical Property:

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Technology Process of tert-Butyl 4-[(5-bromo-3-nitropyridin-2-yl)amino]piperidine-1-carboxylate

There total 1 articles about tert-Butyl 4-[(5-bromo-3-nitropyridin-2-yl)amino]piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

5-bromo-2-chloro-3-nitropyridine (67443-38-3) + 1-(tert-butoxycarbonyl)-4-aminopiperidine (87120-72-7) → tert-Butyl 4-[(5-bromo-3-nitropyridin-2-yl)amino]piperidine-1-carboxylate (1127119-18-9)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In 1-methyl-pyrrolidin-2-one; at 30 ℃;

Reference yield:

tert-Butyl 4-[(5-bromo-3-nitropyridin-2-yl)amino]piperidine-1-carboxylate (1127119-18-9) + 2-Chlorobenzeneboronic acid (3900-89-8) → C21H25ClN4O4

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; water; for 6h; Heating;

DOI:10.1016/j.bioorg.2020.103875

Reference yield:

tert-Butyl 4-[(5-bromo-3-nitropyridin-2-yl)amino]piperidine-1-carboxylate (1127119-18-9) + 3-chlorophenylboronic acid (63503-60-6) → C21H25ClN4O4

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; water; for 6h; Heating;

DOI:10.1016/j.bioorg.2020.103875

upstream raw materials:

5-bromo-2-chloro-3-nitropyridine

1-(tert-butoxycarbonyl)-4-aminopiperidine

Downstream raw materials:

6-(4-(1H-tetrazol-1-yl)phenyl)-3-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)-3H-[1,2,3]triazolo[4,5-b]pyridine

5-(4-(1H-tetrazol-1-yl)phenyl)-N-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)-3-nitropyridin-2-amine

5-(4-(1H-tetrazol-1-yl)phenyl)-N₂-(1-(5-ethylpyrimidin-2-yl)piperidin-4-yl)pyridine-2,3-diamine

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