tert-butyl 1-{4-[(diethylamino)carbonyl]phenyl}-7-hydroxy-6-methoxy-3,4-dihydroisoquinoline-2(1H)-carboxylate

Base Information

• Chemical Name: tert-butyl 1-{4-[(diethylamino)carbonyl]phenyl}-7-hydroxy-6-methoxy-3,4-dihydroisoquinoline-2(1H)-carboxylate
• CAS No.: 857252-56-3
• Molecular Formula: C₂₆H₃₄N₂O₅
• Molecular Weight: 454.566

Synonyms:tert-butyl 1-{4-[(diethylamino)carbonyl]phenyl}-7-hydroxy-6-methoxy-3,4-dihydroisoquinoline-2(1H)-carboxylate

Chemical Property of tert-butyl 1-{4-[(diethylamino)carbonyl]phenyl}-7-hydroxy-6-methoxy-3,4-dihydroisoquinoline-2(1H)-carboxylate

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Technology Process of tert-butyl 1-{4-[(diethylamino)carbonyl]phenyl}-7-hydroxy-6-methoxy-3,4-dihydroisoquinoline-2(1H)-carboxylate

There total 1 articles about tert-butyl 1-{4-[(diethylamino)carbonyl]phenyl}-7-hydroxy-6-methoxy-3,4-dihydroisoquinoline-2(1H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N,N-diethyl-4-(7-hydroxy-6-methoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)benzamide (857252-33-6) + di-tert-butyl dicarbonate (24424-99-5) → tert-butyl 1-{4-[(diethylamino)carbonyl]phenyl}-7-hydroxy-6-methoxy-3,4-dihydroisoquinoline-2(1H)-carboxylate (857252-56-3)

Guidance literature:

With triethylamine; In methanol; at 20 ℃; for 2.5h;

Reference yield: 89.0%

tert-butyl 1-{4-[(diethylamino)carbonyl]phenyl}-7-hydroxy-6-methoxy-3,4-dihydroisoquinoline-2(1H)-carboxylate (857252-56-3) + 3-pyridylboronic acid (1692-25-7) → tert-butyl 1-{4-[(diethylamino)carbonyl]phenyl}-6-methoxy-7-(pyridin-3-yloxy)-3,4-dihydroisoquinoline-2(1H)-carboxylate (857252-60-9)

Guidance literature:

With 4 A molecular sieve; copper diacetate; triethylamine; In dichloromethane; at 20 ℃;

Reference yield: 65.0%

tert-butyl 1-{4-[(diethylamino)carbonyl]phenyl}-7-hydroxy-6-methoxy-3,4-dihydroisoquinoline-2(1H)-carboxylate (857252-56-3) + phenylboronic acid (98-80-6) → tert-butyl 1-{4-[(diethylamino)carbonyl]phenyl}-6-methoxy-7-phenoxy-3,4-dihydroisoquinoline-2(1H)-carboxylate (857252-57-4)

Guidance literature:

With copper diacetate; triethylamine; In dichloromethane; at 20 ℃; for 24h;

upstream raw materials:

N,N-diethyl-4-(7-hydroxy-6-methoxy-1,2,3,4-tetrahydroisoquinolin-1-yl)benzamide

di-tert-butyl dicarbonate

Downstream raw materials:

tert-butyl 1-{4-[(diethylamino)carbonyl]phenyl}-6-methoxy-7-(4-methoxyphenoxy)-3,4-dihydroisoquinoline-2(1H)-carboxylate

tert-butyl 1-{4-[(diethylamino)carbonyl]phenyl}-6-methoxy-7-(pyridin-3-yloxy)-3,4-dihydroisoquinoline-2(1H)-carboxylate

tert-butyl 1-{4-[(diethylamino)carbonyl]phenyl}-7-(4-fluorophenoxy)-6-methoxy-3,4-dihydroisoquinoline-2(1H)-carboxylate

tert-butyl 1-{4-[(diethylamino)carbonyl]phenyl}-6-methoxy-7-phenoxy-3,4-dihydroisoquinoline-2(1H)-carboxylate

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