(E)-1-(6-Methyl-2,4-diphenyl-3,4-dihydro-2H-thiazolo[3,2-a][1,3,5]triazin-7-yl)-3-(4-nitro-phenyl)-propenone

Base Information

• Chemical Name: (E)-1-(6-Methyl-2,4-diphenyl-3,4-dihydro-2H-thiazolo[3,2-a][1,3,5]triazin-7-yl)-3-(4-nitro-phenyl)-propenone
• CAS No.: 87102-43-0
• Molecular Formula: C₂₇H₂₂N₄O₃S
• Molecular Weight: 482.563

Synonyms:(E)-1-(6-Methyl-2,4-diphenyl-3,4-dihydro-2H-thiazolo[3,2-a][1,3,5]triazin-7-yl)-3-(4-nitro-phenyl)-propenone

Chemical Property of (E)-1-(6-Methyl-2,4-diphenyl-3,4-dihydro-2H-thiazolo[3,2-a][1,3,5]triazin-7-yl)-3-(4-nitro-phenyl)-propenone

Chemical Property:

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Technology Process of (E)-1-(6-Methyl-2,4-diphenyl-3,4-dihydro-2H-thiazolo[3,2-a][1,3,5]triazin-7-yl)-3-(4-nitro-phenyl)-propenone

There total 4 articles about (E)-1-(6-Methyl-2,4-diphenyl-3,4-dihydro-2H-thiazolo[3,2-a][1,3,5]triazin-7-yl)-3-(4-nitro-phenyl)-propenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

4-nitrobenzaldehdye (555-16-8) + 1-(6-Methyl-2,4-diphenyl-3,4-dihydro-2H-thiazolo[3,2-a][1,3,5]triazin-7-yl)-ethanone (87102-33-8) → (E)-1-(6-Methyl-2,4-diphenyl-3,4-dihydro-2H-thiazolo[3,2-a][1,3,5]triazin-7-yl)-3-(4-nitro-phenyl)-propenone (87102-43-0)

Guidance literature:

With piperidine; at 160 ℃; for 0.5h;

DOI:10.1021/je00035a032

Reference yield:

4,6-diphenyl[1,3,5]triazinane-2-thione (61582-10-3) → (E)-1-(6-Methyl-2,4-diphenyl-3,4-dihydro-2H-thiazolo[3,2-a][1,3,5]triazin-7-yl)-3-(4-nitro-phenyl)-propenone (87102-43-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 70 percent / 1.) 85percent KOH / ethanol / 1.) 70-80 deg C, 10 min, 2.) room temp., 18 h

2: 60 percent / polyphosphoric acid / 1.) 100 deg C, 1 h, 2.) 120 deg C, 15 min

3: 73 percent / piperidine / 0.5 h / 160 °C

With piperidine; potassium hydroxide; PPA; In ethanol;

DOI:10.1021/je00035a032

Reference yield:

3-chloropentane-2,4-dione (1694-29-7) → (E)-1-(6-Methyl-2,4-diphenyl-3,4-dihydro-2H-thiazolo[3,2-a][1,3,5]triazin-7-yl)-3-(4-nitro-phenyl)-propenone (87102-43-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 70 percent / 1.) 85percent KOH / ethanol / 1.) 70-80 deg C, 10 min, 2.) room temp., 18 h

2: 60 percent / polyphosphoric acid / 1.) 100 deg C, 1 h, 2.) 120 deg C, 15 min

3: 73 percent / piperidine / 0.5 h / 160 °C

With piperidine; potassium hydroxide; PPA; In ethanol;

DOI:10.1021/je00035a032

upstream raw materials:

4-nitrobenzaldehdye

1-(6-Methyl-2,4-diphenyl-3,4-dihydro-2H-thiazolo[3,2-a][1,3,5]triazin-7-yl)-ethanone

4,6-diphenyl[1,3,5]triazinane-2-thione

(E)-3-(4,6-Diphenyl-1,4,5,6-tetrahydro-[1,3,5]triazin-2-ylsulfanyl)-4-hydroxy-pent-3-en-2-one

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