Trifluoro-methanesulfonic acid 4-(2-diethylcarbamoyloxy-3,4-dimethoxy-phenyl)-6-dimethoxymethyl-3-(2,2-dimethyl-propionylamino)-pyridin-2-yl ester

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Chemical Name:Trifluoro-methanesulfonic acid 4-(2-diethylcarbamoyloxy-3,4-dimethoxy-phenyl)-6-dimethoxymethyl-3-(2,2-dimethyl-propionylamino)-pyridin-2-yl ester
CAS No.:186414-02-8
Molecular Formula:C₂₇H₃₆F₃N₃O₁₀S
Molecular Weight:651.658
Hs Code.:

Trifluoro-methanesulfonic acid 4-(2-diethylcarbamoyloxy-3,4-dimethoxy-phenyl)-6-dimethoxymethyl-3-(2,2-dimethyl-propionylamino)-pyridin-2-yl ester

Synonyms:Trifluoro-methanesulfonic acid 4-(2-diethylcarbamoyloxy-3,4-dimethoxy-phenyl)-6-dimethoxymethyl-3-(2,2-dimethyl-propionylamino)-pyridin-2-yl ester

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Chemical Property of Trifluoro-methanesulfonic acid 4-(2-diethylcarbamoyloxy-3,4-dimethoxy-phenyl)-6-dimethoxymethyl-3-(2,2-dimethyl-propionylamino)-pyridin-2-yl ester

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Technology Process of Trifluoro-methanesulfonic acid 4-(2-diethylcarbamoyloxy-3,4-dimethoxy-phenyl)-6-dimethoxymethyl-3-(2,2-dimethyl-propionylamino)-pyridin-2-yl ester

There total 7 articles about Trifluoro-methanesulfonic acid 4-(2-diethylcarbamoyloxy-3,4-dimethoxy-phenyl)-6-dimethoxymethyl-3-(2,2-dimethyl-propionylamino)-pyridin-2-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 131653-74-2
3,4-dimethoxy-2-(N,N-diethylcarbamoyloxy)phenylboronic acid

: 186414-00-6
Trifluoro-methanesulfonic acid 6-dimethoxymethyl-3-(2,2-dimethyl-propionylamino)-4-iodo-pyridin-2-yl ester

: 186414-02-8
Trifluoro-methanesulfonic acid 4-(2-diethylcarbamoyloxy-3,4-dimethoxy-phenyl)-6-dimethoxymethyl-3-(2,2-dimethyl-propionylamino)-pyridin-2-yl ester

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In ethanol; toluene; at 110 ℃; for 2h;
DOI:10.1002/jhet.5570330670

Reference yield:

: 186413-93-4
N-(6-Formyl-4-iodo-2-oxo-1,2-dihydro-pyridin-3-yl)-2,2-dimethyl-propionamide

: 186414-02-8
Trifluoro-methanesulfonic acid 4-(2-diethylcarbamoyloxy-3,4-dimethoxy-phenyl)-6-dimethoxymethyl-3-(2,2-dimethyl-propionylamino)-pyridin-2-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 98 percent / HCl / methanol / 6 h / Heating

2: 91 percent / pyridine / 25 h / Ambient temperature

3: 75 percent / K₂CO₃, Pd(PPh₃)4 / toluene; ethanol / 2 h / 110 °C

With pyridine; hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In methanol; ethanol; toluene;
DOI:10.1002/jhet.5570330670

Reference yield:

: 186413-83-2
N-(2-Isopropoxy-6-vinyl-pyridin-3-yl)-2,2-dimethyl-propionamide

: 186414-02-8
Trifluoro-methanesulfonic acid 4-(2-diethylcarbamoyloxy-3,4-dimethoxy-phenyl)-6-dimethoxymethyl-3-(2,2-dimethyl-propionylamino)-pyridin-2-yl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 90 percent / O₃, AcOH / CH₂Cl₂ / 0.42 h / -78 °C

2: 95 percent / p-toluenesulfonic acid / toluene / 12 h / Heating

3: 1.) n-BuLi, tetramethylethylenediamine, 2.) I₂ / 1.) THF, hexane, a) -78 deg C, 15 min, b) -25 deg C, 45 min, 2.) THF, hexane, a) -78 deg C, 15 min, b) -25 deg C, 3 h

4: 60 percent / BBr₃ / CH₂Cl₂ / 10 h / Ambient temperature

5: 98 percent / HCl / methanol / 6 h / Heating

6: 91 percent / pyridine / 25 h / Ambient temperature

7: 75 percent / K₂CO₃, Pd(PPh₃)4 / toluene; ethanol / 2 h / 110 °C

With pyridine; hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; iodine; boron tribromide; potassium carbonate; toluene-4-sulfonic acid; ozone; acetic acid; In methanol; ethanol; dichloromethane; toluene;
DOI:10.1002/jhet.5570330670