benzyl (2S,3S)-2-but-3-enyl-5-oxo-3-[(R)-1-(2,4,6-triisopropylphenyl)ethoxy]pyrrolidine-1-carboxylate

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Chemical Name:benzyl (2S,3S)-2-but-3-enyl-5-oxo-3-[(R)-1-(2,4,6-triisopropylphenyl)ethoxy]pyrrolidine-1-carboxylate
CAS No.:306739-80-0
Molecular Formula:C₃₃H₄₅NO₄
Molecular Weight:519.725
Hs Code.:

Synonyms:benzyl (2S,3S)-2-but-3-enyl-5-oxo-3-[(R)-1-(2,4,6-triisopropylphenyl)ethoxy]pyrrolidine-1-carboxylate

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Chemical Property of benzyl (2S,3S)-2-but-3-enyl-5-oxo-3-[(R)-1-(2,4,6-triisopropylphenyl)ethoxy]pyrrolidine-1-carboxylate

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Technology Process of benzyl (2S,3S)-2-but-3-enyl-5-oxo-3-[(R)-1-(2,4,6-triisopropylphenyl)ethoxy]pyrrolidine-1-carboxylate

There total 2 articles about benzyl (2S,3S)-2-but-3-enyl-5-oxo-3-[(R)-1-(2,4,6-triisopropylphenyl)ethoxy]pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 501-53-1,94274-21-2
benzyl chloroformate

: 306739-88-8
(4S,5S)-5-but-3-enyl-4-[(R)-1-(2,4,6-triisopropylphenyl)ethoxy]pyrrolidin-2-one

: 306739-80-0
benzyl (2S,3S)-2-but-3-enyl-5-oxo-3-[(R)-1-(2,4,6-triisopropylphenyl)ethoxy]pyrrolidine-1-carboxylate

Guidance literature:: (4S,5S)-5-but-3-enyl-4-[(R)-1-(2,4,6-triisopropylphenyl)ethoxy]pyrrolidin-2-one; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

benzyl chloroformate; In tetrahydrofuran; at 0 ℃; for 1h; Further stages.;
DOI:10.1021/jo0005621

Reference yield:

: 306739-76-4
(4S,5S)-5-but-3-enyl-3,3-dichloro-4-[(R)-1-(2,4,6-triisopropylphenyl)ethoxy]pyrrolidin-2-one

: 306739-80-0
benzyl (2S,3S)-2-but-3-enyl-5-oxo-3-[(R)-1-(2,4,6-triisopropylphenyl)ethoxy]pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: 3.16 g / NH₄Cl; Zmn-Cu / methanol

2.1: n-BuLi / tetrahydrofuran; hexane / 0.5 h / -78 °C

2.2: 92 percent / tetrahydrofuran / 1 h / 0 °C

With n-butyllithium; copper; ammonium chloride; zinc; In tetrahydrofuran; methanol; hexane; 1.1: Dehalogenation / 2.1: Metallation / 2.2: Acylation;
DOI:10.1021/jo0005621