Methyl 5-[(benzyloxy)methyl]-5-[(4-methoxyphenoxy)methyl]tetrahydro-2-furancarboxylate

Base Information

Chemical Name:Methyl 5-[(benzyloxy)methyl]-5-[(4-methoxyphenoxy)methyl]tetrahydro-2-furancarboxylate
CAS No.:367263-50-1
Molecular Formula:C₂₃H₂₈O₆
Molecular Weight:400.472
Hs Code.:

Synonyms:Methyl 5-[(benzyloxy)methyl]-5-[(4-methoxyphenoxy)methyl]tetrahydro-2-furancarboxylate

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Chemical Property of Methyl 5-[(benzyloxy)methyl]-5-[(4-methoxyphenoxy)methyl]tetrahydro-2-furancarboxylate

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Technology Process of Methyl 5-[(benzyloxy)methyl]-5-[(4-methoxyphenoxy)methyl]tetrahydro-2-furancarboxylate

There total 9 articles about Methyl 5-[(benzyloxy)methyl]-5-[(4-methoxyphenoxy)methyl]tetrahydro-2-furancarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 367263-49-8
5-benzyloxymethyl-5-(4-methoxy-benzyloxymethyl)-tetrahydro-furan-2-carboxylic acid

: 18107-18-1
diazomethyl-trimethyl-silane

: 367263-50-1
Methyl 5-[(benzyloxy)methyl]-5-[(4-methoxyphenoxy)methyl]tetrahydro-2-furancarboxylate

Guidance literature:: In tetrahydrofuran; methanol; hexane; at 20 ℃; for 2h;
DOI:10.1016/S0014-827X(01)01077-1

Reference yield:

: 108836-41-5
2-((4-methoxybenzyloxy)methyl)oxirane

: 367263-50-1
Methyl 5-[(benzyloxy)methyl]-5-[(4-methoxyphenoxy)methyl]tetrahydro-2-furancarboxylate

Guidance literature:: Multi-step reaction with 8 steps

1.1: NaH / dimethylformamide / 0.33 h / 20 °C

1.2: 90 percent / dimethylformamide / 4 h / 80 °C

2.1: 92 percent / PCC; molecular sieves 4 Angstroem / CH₂Cl₂ / 24 h / 20 °C

3.1: Mg / tetrahydrofuran / -10 - 20 °C

3.2: 80 percent / CH₂Br₂ / tetrahydrofuran / 14 h / 20 °C

4.1: 85 percent / OsO₄; NMO; aq. NaIO₄ / acetone / 30 h / 20 °C

5.1: 83 percent / aq. HCl / acetic acid / 0.08 h / 20 °C

6.1: 50 percent / toluene; tetrahydrofuran / 7 h / 20 °C

7.1: 72 percent / aq. NaOH / ethanol / 8 h / Heating

8.1: 84 percent / tetrahydrofuran; methanol; hexane / 2 h / 20 °C

With hydrogenchloride; sodium hydroxide; sodium periodate; osmium(VIII) oxide; N-methyl-2-indolinone; 4 A molecular sieve; sodium hydride; magnesium; pyridinium chlorochromate; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; acetic acid; N,N-dimethyl-formamide; acetone; toluene;
DOI:10.1016/S0014-827X(01)01077-1

Reference yield:

: 162427-33-0
1-benzyloxy-3-(p-methoxybenzyloxy)propan-2-ol

: 367263-50-1
Methyl 5-[(benzyloxy)methyl]-5-[(4-methoxyphenoxy)methyl]tetrahydro-2-furancarboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: 92 percent / PCC; molecular sieves 4 Angstroem / CH₂Cl₂ / 24 h / 20 °C

2.1: Mg / tetrahydrofuran / -10 - 20 °C

2.2: 80 percent / CH₂Br₂ / tetrahydrofuran / 14 h / 20 °C

3.1: 85 percent / OsO₄; NMO; aq. NaIO₄ / acetone / 30 h / 20 °C

4.1: 83 percent / aq. HCl / acetic acid / 0.08 h / 20 °C

5.1: 50 percent / toluene; tetrahydrofuran / 7 h / 20 °C

6.1: 72 percent / aq. NaOH / ethanol / 8 h / Heating

7.1: 84 percent / tetrahydrofuran; methanol; hexane / 2 h / 20 °C

With hydrogenchloride; sodium hydroxide; sodium periodate; osmium(VIII) oxide; N-methyl-2-indolinone; 4 A molecular sieve; magnesium; pyridinium chlorochromate; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; acetic acid; acetone; toluene;
DOI:10.1016/S0014-827X(01)01077-1