(E)-3-(3-(3-((2-bromophenyl)amino)-2-oxoindolin-3-yl)prop-1-en-1-yl)-4-fluorobenzonitrile

Base Information

Chemical Name:(E)-3-(3-(3-((2-bromophenyl)amino)-2-oxoindolin-3-yl)prop-1-en-1-yl)-4-fluorobenzonitrile
CAS No.:1412900-57-2
Molecular Formula:C₂₄H₁₇BrFN₃O
Molecular Weight:462.321
Hs Code.:

Synonyms:(E)-3-(3-(3-((2-bromophenyl)amino)-2-oxoindolin-3-yl)prop-1-en-1-yl)-4-fluorobenzonitrile

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Chemical Property of (E)-3-(3-(3-((2-bromophenyl)amino)-2-oxoindolin-3-yl)prop-1-en-1-yl)-4-fluorobenzonitrile

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Technology Process of (E)-3-(3-(3-((2-bromophenyl)amino)-2-oxoindolin-3-yl)prop-1-en-1-yl)-4-fluorobenzonitrile

There total 5 articles about (E)-3-(3-(3-((2-bromophenyl)amino)-2-oxoindolin-3-yl)prop-1-en-1-yl)-4-fluorobenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 24.0%

: 1149390-43-1
3-allyl-3-((2-bromophenyl)amino)indolin-2-one

: 1260539-05-6
4-fluoro-3-vinylbenzonitrile

: 1412900-57-2
(E)-3-(3-(3-((2-bromophenyl)amino)-2-oxoindolin-3-yl)prop-1-en-1-yl)-4-fluorobenzonitrile

Guidance literature:: With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In dichloromethane; for 24h; Inert atmosphere; Reflux;
DOI:10.1016/j.tet.2012.09.036

Reference yield:

: 33829-01-5
1,3-dihydro-3-[(2-bromophenyl)imino]-2H-indol-2-one

: 1412900-57-2
(E)-3-(3-(3-((2-bromophenyl)amino)-2-oxoindolin-3-yl)prop-1-en-1-yl)-4-fluorobenzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: indium; sodium iodide / N,N-dimethyl-formamide / Inert atmosphere

2: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 24 h / Inert atmosphere; Reflux

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; indium; sodium iodide; In dichloromethane; N,N-dimethyl-formamide; 2: |Grubbs Olefin Metathesis;
DOI:10.1016/j.tet.2012.09.036

Reference yield:

: 91-56-5,1186480-61-4,84788-92-1
indole-2,3-dione

: 1412900-57-2
(E)-3-(3-(3-((2-bromophenyl)amino)-2-oxoindolin-3-yl)prop-1-en-1-yl)-4-fluorobenzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: toluene-4-sulfonic acid / chloroform / 48 h / Inert atmosphere; Reflux

2: indium; sodium iodide / N,N-dimethyl-formamide / Inert atmosphere

3: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 24 h / Inert atmosphere; Reflux

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; indium; toluene-4-sulfonic acid; sodium iodide; In dichloromethane; chloroform; N,N-dimethyl-formamide; 3: |Grubbs Olefin Metathesis;
DOI:10.1016/j.tet.2012.09.036